Tidal volume VT required for mouth-to-mouth (MTM) and bag-valve-mask (BVM) rescue ventilation remains debatable owing to differences in physiology and end-point objectives. Analysis of gas transport may clarify minimum necessary VT and its determinants. Alveolar and arterial O2 and CO2 responses to MTM and air BVM ventilation for VT between 0.4 and 1.2 liters were computed using a model of gas exchange that incorporates inspired gas concentrations, airway dead space, cardiac output, pulmonary shunt, blood gas dissociation curves, tissue compartments, and metabolic rate. Parameters were adjusted to match published human data. Steady state arterial oxygen saturation reached plateaus at VT above 0.7 liters with MTM and 0.6 liters with air ventilation at 12 breaths per minute. Increasing shunt shifted oxygenation plateaus downward, but larger tidal volumes did not improve oxygen saturation. Carbon dioxide retention occurred at VT below 2.3 liters for MTM ventilation and 0.6 liters for air ventilation. Results establish a physiological foundation for tidal volume requirements during resuscitation.

中文翻译：

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潮气量对营救通风过程中气体交换的影响。

由于生理和终点目标的差异，口对口（MTM）和袋阀面罩（BVM）抢救通气所需的潮气量VT仍值得商bat。气体传输的分析可以阐明最小必要的VT及其决定因素。使用包含交换气体浓度，气道死腔，心排血量，心输出量，肺分流，血气解离曲线，组织的气体交换模型，计算了MTM和空气BVM通气对VT在0.4至1.2升之间的肺泡和动脉O2和CO2响应隔室和新陈代谢率。调整参数以匹配已发布的人类数据。使用MTM时，VT高于0.7升时，稳态动脉血氧饱和度达到平稳状态，而每分钟进行12次呼吸时，采用通气时，稳态氧饱和度达到0.6升。越来越多的分流器使充氧平台向下移动，但是较大的潮气量并不能提高氧饱和度。对于MTM通风，VT处的二氧化碳滞留量低于2.3升，对于空气通风，二氧化碳的保留量低于0.6升。结果为复苏过程中的潮气量需求奠定了生理基础。