Background

Candida yeasts are considered the main agents of nosocomial fungal infections.

Aims

This study aimed to establish the epidemiological profile of patients with candiduria hospitalized in the capital of the State of Mato Grosso, in the Central-Western region of Brazil.

Methods

Patients from three private hospitals and a public hospital participated in the study. This was an observational and cross-sectional study including analysis of patients mortality. It was carried out from March to August 2015.

Results

A total of 93 patients with candiduria were evaluated. Candida tropicalis was found most commonly (37.6%; n = 35), followed by Candida albicans (36.6%; n = 34), Candida glabrata (19.3%; n = 18), psilosis complex (4.3%; n = 4), Candida lusitaniae (1.1%; n = 1) and Candida krusei (1.1%; n = 1). Antibiotic therapy (100%) and the use of an indwelling urinary catheter (89.2%; n = 83) were the most frequent predisposing factors. Antifungal treatment was given to 65.6% of the patients, and anidulafungin was the most used antifungal. Mortality rates were 48% higher among patients with candiduria who had renal failure. Micafungin was the antifungal most prescribed among the patients who died. Candidemia concomitant with candiduria occurred in eight (8.6%; n = 8) cases. Considering the species recovered in the blood and urine, only one patient had genetically distinct clinical isolates.

Conclusions

Non-C. albicans Candida species were predominant, with C. tropicalis being the most responsible for most cases of candiduria.

中文翻译：

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巴西中西部地区念珠菌病住院患者的流行病学概况。

背景

念珠菌被认为是医院内真菌感染的主要因素。

目的

这项研究旨在确定在巴西中西部地区马托格罗索州首府住院的念珠菌患者的流行病学概况。

方法

来自三家私立医院和一家公立医院的患者参加了这项研究。这是一项观察性和横断面研究，包括对患者死亡率的分析。该活动于2015年3月至8月进行。

结果

总共评估了93名念珠菌患者。热带假丝酵母中发现最常用（37.6％; ñ  = 35），其次是白色念珠菌（36.6％; ñ  = 34），光滑念珠菌（19.3％; ñ  = 18），psilosis复合物（4.3％; ñ  = 4），lusitaniae念珠菌（1.1％; n  = 1）和krusei念珠菌（1.1％; n  = 1）。抗生素治疗（100％）和使用导尿管（89.2％; n = 83）是最常见的诱发因素。65.6％的患者接受了抗真菌治疗，而阿尼芬净为最常用的抗真菌药物。肾功能衰竭念珠菌病患者的死亡率高48％。在死者中，米卡芬净是最常用的抗真菌药物。 8例（8.6％；n = 8）病例中伴有念珠菌性念珠菌血症。考虑到从血液和尿液中回收的物种，只有一名患者具有遗传上不同的临床分离株。

结论

非白色念珠菌念珠菌种类占主导地位，热带念珠菌是大多数念珠菌病例的最主要原因。