Neonatal Hypoxia‐Ischemia (HI) is a major cause of morbidity and mortality, and is frequently associated with short and long‐term neurologic and cognitive impairments. The HI injury causes mitochondrial damage leading to increased production of reactive oxygen species (ROS). Phytoestrogens are non‐steroidal plant substances structurally and functionally similar to estrogen. Coumestrol is a potent isoflavonoid with a protective effect against ischemic brain damage in adult rats. Our aim was to determine if coumestrol treatment following neonatal HI attenuates the long‐term cognitive deficits induced by neonatal HI, as well as to investigate one possible mechanism underlying its potential effect.

中文翻译：

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植物雌激素香豆雌酚减轻新生儿缺氧缺血后的脑线粒体功能障碍和长期认知缺陷

新生儿缺氧缺血 (HI) 是发病率和死亡率的主要原因，并且经常与短期和长期的神经和认知障碍有关。HI 损伤导致线粒体损伤，导致活性氧 (ROS) 的产生增加。植物雌激素是一种非甾体植物物质，在结构和功能上与雌激素相似。Coumestrol 是一种有效的异黄酮类化合物，对成年大鼠的缺血性脑损伤具有保护作用。我们的目的是确定新生儿 HI 后的香豆雌酚治疗是否能减轻新生儿 HI 引起的长期认知缺陷，并研究其潜在影响的一种可能机制。