Increasing evidence demonstrates that electric stimulation has anticonvulsant effects. The present study was undertaken to investigate the effects of mild foot electrical stimulation (MFES) on the development of pentylenetetrazol (PTZ) kindling and compare its effectiveness with the more commonly used treatment, phenytoin. Kindling was induced in rats by repeated injections (every 24 h) of PTZ (37.5 mg/kg). The rats were subjected to either MFES (0.2 mA in intensity for a 160 ms duration with a 160 ms interval for 20 min) or phenytoin (30 mg/kg) before PTZ injections. Following this treatment, rats received MFES every other day for 10 days or 26 days after establishment of PTZ kindling. The data showed that MFES significantly inhibited development of chemical kindling induced by PTZ in rats (p = 0.001, as compared to PTZ-treated animals). This inhibitory effect is comparable with the effect of 30 mg/kg doses of phenytoin (P = 0.99, as compared to phenytoin group). However, 10 days or 26 days durations of MFES had no effect on established kindled seizures (P = 0.58 as compared to PTZ-treated animals). Our data demonstrate that although MFES significantly inhibited the development of chemical kindling, this experimental paradigm had no effect on established kindled seizures.

中文翻译：

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轻度足部电刺激在抑制大鼠戊四氮引起的点燃方面与苯妥英相当。


越来越多的证据表明电刺激具有抗惊厥作用。本研究旨在调查轻度足部电刺激（MFES）对戊四唑（PTZ）点燃的影响，并将其与更常用的治疗方法苯妥英钠的有效性进行比较。通过重复注射（每 24 小时）PTZ（37.5 mg/kg）在大鼠中诱导点燃。在注射 PTZ 之前，对大鼠进行 MFES（强度为 0.2 mA，持续时间为 160 毫秒，间隔 160 毫秒，持续时间为 20 分钟）或苯妥英钠（30 毫克/千克）。在这种治疗之后，在建立 PTZ 引火后，大鼠每隔一天接受一次 MFES，持续 10 天或 26 天。数据显示，MFES 显着抑制大鼠体内由 PTZ 诱导的化学点燃的发展（与 PTZ 处理的动物相比，p = 0.001）。这种抑制作用与 30 mg/kg 剂量苯妥英的效果相当（与苯妥英组相比，P = 0.99）。然而，10 天或 26 天的 MFES 持续时间对已建立的点燃癫痫发作没有影响（与 PTZ 处理的动物相比，P = 0.58）。我们的数据表明，尽管 MFES 显着抑制了化学点燃的发展，但该实验范式对已建立的点燃癫痫发作没有影响。