There has been a growing emphasis on understanding the important relationship between human-associated microbial communities and disease development. With technological advancements, we are able to gain further insights into host-microbiome interactions at a deeper level. In order to fully leverage the close associations between microbes and their host, development of therapeutics targeting the microbiome has surged in recent years. In this review, we discuss advances made in engineering gut bacteria to develop novel therapeutic modalities that aim to rewire host-microbiome interactions such as host metabolism and immune functions for prevention and treatment of various diseases. In particular, applications of these engineered bacteria against diseases such as metabolic, immune disorders and cancer are covered.

中文翻译：

---

工程化共生细菌以重新建立宿主-微生物组的相互作用。

人们越来越重视理解与人类相关的微生物群落与疾病发展之间的重要关系。随着技术的进步，我们能够更深入地了解宿主-微生物组的相互作用。为了充分利用微生物与其宿主之间的紧密联系，近年来，针对微生物组的疗法的发展迅速。在这篇综述中，我们讨论了在工程肠道细菌方面取得的进展，以开发新颖的治疗方法，旨在重新改造宿主-微生物组的相互作用，例如宿主代谢和免疫功能，以预防和治疗各种疾病。特别地，涵盖了这些工程菌对诸如代谢，免疫疾病和癌症的疾病的应用。