The aim of this study was to investigate the effect of activated ghrelin with dietary octanoic acids or medium-chain triglyceride (MCT) administration to underweight patient with chronic obstructive pulmonary disease (COPD). Eleven severe and very severe COPD patients received a 5-day treatment with edible MCT. Sequentially, 10 patients received a 3-week combination treatment with MCT and intravenous acyl ghrelin. Five-day MCT treatment increased endogenous acyl ghrelin (p = 0.0049), but the total ghrelin level was unchanged. MCT-ghrelin combination treatment improved the peak oxygen uptake (p = 0.0120) during whole treatment course. This effect was attributed to the resultant improvements in cardiac function by O2 pulse, and to the difference between inspired and expired oxygen concentration rather than minute ventilation. Addition of dietary MCT to ghrelin treatment improved the aerobic capacity of underweight COPD patients, likely by mechanisms of increased O2 delivery through improvements in primary cardiocirculatory and muscular crosstalk.

中文翻译：

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一项关于中链甘油三酯和生长素释放肽联合治疗慢性阻塞性肺疾病患者的 II 期、开放标签临床试验。


本研究的目的是探讨活性生长素释放肽与膳食辛酸或中链甘油三酯 (MCT) 联合给药对体重过轻的慢性阻塞性肺疾病 (COPD) 患者的影响。 11 名严重和非常严重的 COPD 患者接受了为期 5 天的食用 MCT 治疗。随后，10 名患者接受了 MCT 和静脉注射酰基胃饥饿素为期 3 周的联合治疗。五天的 MCT 治疗增加了内源性酰基生长素释放肽 (p = 0.0049)，但总生长素释放肽水平没有变化。 MCT-胃饥饿素联合治疗改善了整个治疗过程中的峰值摄氧量（p = 0.0120）。这种效果归因于氧脉冲对心脏功能的改善，以及吸入氧浓度和呼出氧浓度之间的差异，而不是每分钟通气量。在生长素释放肽治疗中添加膳食中链甘油酯可以改善体重不足的慢性阻塞性肺病患者的有氧能力，这可能是通过改善初级心脏循环和肌肉串扰来增加氧气输送的机制。