PURPOSE In the United States, approximately 45% of persons living with HIV (PLHIV) are ≥ 50 years of age. Many older PLHIV have multi-morbidities that complicate HIV infection and/or interfere with, or are exacerbated by, antiretroviral treatment. Physical health symptoms and psychiatric disorders, particularly depression, can worsen life quality in older PLHIV. METHODS This study assessed associations among physical symptoms, indicators of HIV-related health status (i.e., time since diagnosis; ever diagnosed with AIDS; having attained viral suppression), depressive symptoms, and health-related quality of life (HRQoL) in older PLHIV. Regression analyses examined data from 296 PLHIV ≥ 50 years of age living in Cincinnati, OH, Columbus, OH, and New York City. RESULTS Depressive symptoms and physical symptoms, particularly those related to appearance and sexual functioning, most strongly predicted HRQoL. Indicators of HIV health status did not significantly predict HRQoL. Depressive symptoms were a particularly robust predictor of HRQoL, even when accounting for physical health symptoms. CONCLUSION Findings suggest that symptom management is critical to HRQoL in older PLHIV, and symptoms related to physical appearance and sexual functioning should not be overlooked in this growing population.

中文翻译：

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感染艾滋病毒的老年人的抑郁症状、身体症状和与健康相关的生活质量。

目的 在美国，大约 45% 的 HIV 感染者 (PLHIV) 年龄≥50 岁。许多老年 PLHIV 具有多种疾病，使 HIV 感染复杂化和/或干扰抗逆转录病毒治疗，或因抗逆转录病毒治疗而加重。身体健康症状和精神疾病，尤其是抑郁症，会恶化老年 PLHIV 的生活质量。方法 本研究评估了老年 PLHIV 的身体症状、与 HIV 相关的健康状况指标（即，自诊断以来的时间；曾经被诊断患有 AIDS；已获得病毒抑制）、抑郁症状和健康相关生活质量 (HRQoL) 之间的关联。 . 回归分析检查了居住在俄亥俄州辛辛那提、俄亥俄州哥伦布市和纽约市的 296 名 50 岁以上 PLHIV 的数据。结果抑郁症状和身体症状，特别是那些与外观和性功能相关的，最强烈地预测 HRQoL。HIV 健康状况指标并不能显着预测 HRQoL。抑郁症状是 HRQoL 的一个特别有力的预测指标，即使考虑到身体健康症状也是如此。结论 研究结果表明，症状管理对老年 PLHIV 的 HRQoL 至关重要，在这个不断增长的人群中，不应忽视与外貌和性功能相关的症状。