A strict adequate perfusion pressure via arterial baroreflex for the delivery of oxygen to the tissues of the body is well established; however, the importance of baroreflex for cerebral blood flow (CBF) is unclear. On the other hand, there is convincing evidence for arterial baroreflex function playing an important role in maintaining brain homeostasis, e.g., cerebral metabolism, cerebral hemodynamics, and cognitive function. For example, mild cognitive impairment attenuates the sensitivity of baroreflex, and Alzheimer's disease further decreases it. These clinical findings suggest that CBF and cerebral function are affected by systemic blood pressure regulation via the arterial baroreflex. However, dysfunction of arterial baroreflex is likely to affect CBF regulation as well as the underlying neuronal function, but identifying how this is achieved is arduous since neurological diseases affect systemic as well as cerebral circulation independently. Recent insights into the influence of blood pressure regulation via the arterial baroreflex on cerebral function and blood flow regulation may help elucidate this important question. This review summarizes some update findings regarding direct (autonomic regulation) and indirect (systemic blood pressure regulation) contributions of the arterial baroreflex to the maintenance of cerebral vasculature regulation.

中文翻译：

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脑血流调节和认知功能：动脉压力反射功能的作用。


通过动脉压力反射将氧气输送到身体组织的严格的足够灌注压已得到充分确立；然而，压力反射对于脑血流（CBF）的重要性尚不清楚。另一方面，有令人信服的证据表明动脉压力感受反射功能在维持脑稳态（例如脑代谢、脑血流动力学和认知功能）中发挥着重要作用。例如，轻度认知障碍会减弱压力反射的敏感性，而阿尔茨海默氏病会进一步降低压力反射的敏感性。这些临床结果表明，CBF 和脑功能通过动脉压力反射受到全身血压调节的影响。然而，动脉压力反射功能障碍可能会影响 CBF 调节以及潜在的神经元功能，但确定这是如何实现的却很困难，因为神经系统疾病独立影响全身和脑循环。最近对通过动脉压力反射调节血压对大脑功能和血流调节的影响的见解可能有助于阐明这个重要问题。本综述总结了有关动脉压力反射对维持脑血管系统调节的直接（自主调节）和间接（全身血压调节）贡献的一些最新发现。