Subtotal colectomy is usually the therapy of choice in Lynch syndrome patients diagnosed with colon cancer. In patients who develop cancer after the age of 50–60 years, segmental colectomy is considered a good alternative. Although the endoscopic treatment of early colorectal cancer in non-Lynch patients has increased in the last decades, almost all patients with a Lynch syndrome-associated colorectal malignancy undergo surgery, even if the tumour is diagnosed in a (very) early stage. One of the endoscopic treatment options for early colorectal cancer is an endoscopic full thickness resection (eFTR). This treatment modality allows optimal pathological examination of the resection specimen, as a transmural resection is performed with optimal T-staging of the tumour. We report a case of a 62 year old man, diagnosed with MSH2-Lynch syndrome, who underwent successful eFTR treatment of an early (pT1) colon cancer located in the ascending colon, with no signs of recurrence 12 months after treatment. We discuss the pros and cons of endoscopic resection of early colorectal carcinoma in Lynch syndrome patients.

中文翻译：

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内镜全厚度切除术可用于Lynch综合征的早期结肠癌。

大肠切除术通常是诊断为结肠癌的Lynch综合征患者的首选治疗方法。对于50-60岁后患癌症的患者，节段性结肠切除术被认为是一个很好的选择。尽管在过去的几十年中，非林奇患者对早期大肠癌的内镜治疗有所增加，但几乎所有与林奇综合征相关的大肠恶性肿瘤患者都接受了手术治疗，即使在（非常）早期就诊断出了肿瘤。早期大肠癌的内镜治疗选择之一是内镜全厚度切除术（eFTR）。这种治疗方式允许对切除标本进行最佳病理检查，因为透壁切除术是在肿瘤的最佳T期进行的。我们报告了一例62岁的男性，被诊断出患有MSH2-Lynch综合征，他们成功地对位于上升结肠中的早期（pT1）结肠癌进行了eFTR治疗，治疗后12个月没有复发迹象。我们讨论了Lynch综合征患者早期大肠癌内镜切除术的利弊。