Glyphosate is used in Ghana on many crops including yam. There is the suspicion that there could be residue problems in the yam crop. Glyphosate as a polar compound is noted for its difficulty to be analysed in biological matrices. In this study, the method for glyphosate analysis based on FMOC-Cl derivatization was modified with a clean-up (CH₂Cl₂) step and validated to analyse glyphosate in yam by LC-MS/MS. The results showed that the validated method was efficient for the analysis of glyphosate in yam, with recoveries of 34%, linearity of 0.997, RSD of 7%, LOD of 0.04 mg kg⁻¹, and LOQ of 0.12 mg kg⁻¹. Out of 68 samples analysed from a field experiment and from markets, glyphosate was detected in 14 samples, but at levels below the LOQ. It is concluded that the yam contained glyphosate residues at very low levels which may not pose threat to human health.

加纳的许多作物都使用草甘膦，其中包括山药。有人怀疑山药作物可能存在残留问题。草甘膦作为一种极性化合物，因其难以在生物基质中进行分析而闻名。在本研究中，基于 FMOC-Cl 衍生化的草甘膦分析方法经过净化 (CH ₂ Cl ₂ ) 步骤进行修改，并经过验证可通过 LC-MS/MS 分析山药中的草甘膦。结果表明，经验证的方法可有效分析山药中的草甘膦，回收率为34%，线性为0.997，RSD为7%，LOD为0.04 mg kg ⁻¹ ，LOQ为0.12 mg kg ⁻¹ 。在现场实验和市场分析的 68 个样品中，有 14 个样品检测到草甘膦，但含量低于 LOQ。结论是，山药中草甘膦残留量极低，不会对人体健康构成威胁。