Around 10–20% of gastric cancer patients have relatives with a diagnosis of GC and in 1–3% of patients a genetic cause can be confirmed. Histopathologically, GC is classified into intestinal-type, with glandular growth, and diffuse-type with poorly cohesive growth pattern often with signet ring cells. Familial or hereditary GC is classified into hereditary diffuse GC (HDGC), familial intestinal GC (FIGC) and polyposis forms. This review focuses on recent research findings and new concepts of hereditary GC.

中文翻译：

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遗传性胃癌：新变化？更新2013-2018。

约有10–20％的胃癌患者的亲戚诊断为GC，而在1-3％的患者中，可以确定遗传原因。从组织病理学上讲，GC可分为具有腺体生长的肠型和具有印戒细胞的内聚性生长模式差的弥散型。家族性或遗传性GC分为遗传性弥散性GC（HDGC），家族性肠GC（FIGC）和息肉病形式。这篇综述着重于遗传GC的最新研究结果和新概念。