Unintended effects of transgenic rice revealed by transcriptome and metabolism.,GM Crops & Food

当前位置： X-MOL 学术 › GM Crops Food › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Unintended effects of transgenic rice revealed by transcriptome and metabolism.
GM Crops & Food ( IF 4.5 ) Pub Date : 2019-04-09 , DOI: 10.1080/21645698.2019.1598215
Wei Fu ₁ , Chenguang Wang _{1,

2,

3} , Wenjie Xu _{1,

2,

3} , Pengyu Zhu ₁ , Yun Lu ₁ , Shuang Wei ₄ , Xiyang Wu ₅ , Yuping Wu ₁ , Yiqiang Zhao ₂ , Shuifang Zhu _{1,

3}

Affiliation

Genetically modified (GM) organisms have been developed for decades. However, unintended effects are the main concerns of safety assessment that needs to be carefully investigated. Here, eight varieties of GM rice that were developed in China were selected to assess the unintended effects through transcriptome and metabolism. There are 2892-8758 differentially expressed genes (DEGs) and 7-50 metabolites at significant level between GM varieties and their isogenic counterparts, which were far fewer than that between traditional rice varieties. The function enrichment analysis showed altered transcription in stress-related pathway and starch and sucrose metabolism. DEGs shared among eight GM samples constitute less than 1% of the genes in the genome, and none of them is reported more than four times. The insertion effect on the nearby gene expression and the associated metabolism is only restricted to 50 genes. All the results provide a comprehensive analysis of unintended effects and indication of difference in Chinese transgenic rice based on their backgrounds, transformation, and insertion elements.

更新日期：2019-11-01

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文