PURPOSE To investigate the effect of reader experience and zonal location on the occurrence of false positives (FPs) in PIRADS (V2) 3, 4, and 5 lesions on multiparametric (MP)-MRI of the prostate. MATERIALS AND METHODS This retrospective study included 139 patients who had consecutively undergone an MP-MRI of the prostate in combination with a transrectal ultrasound MRI fusion-guided biopsy between 2014 and 2017. MRI exams were prospectively read by a group of inexperienced radiologists (cohort 1; 54 patients) and an experienced radiologist (cohort 2; 85 patients). Multivariable logistic regression analysis was performed to determine the association of experience of the radiologist and zonal location with a FP reading. FP rates were compared between readings by inexperienced and experienced radiologists according to zonal location, using Chi-square (χ2) tests. RESULTS A total of 168 lesions in 139 patients were detected. Median patient age was 68 years (Interquartile range (IQR) 62.5-73), and median PSA was 10.9 ng/mL (IQR 7.6-15.9) for the entire patient cohort. According to multivariable logistic regression, inexperience of the radiologist was significantly (P = 0.044, odds ratio 1.927, 95% confidence interval [CI] 1.017-3.651) and independently associated with a FP reading, while zonal location was not (P = 0.202, odds ratio 1.444, 95% CI 0.820-2.539). In the transition zone (TZ), the FP rate of the inexperienced radiologists 59% (17/29) was significantly higher (χ2P = 0.033) than that of the experienced radiologist 33% (13/40). CONCLUSION Inexperience of the radiologist is significantly and independently associated with a FP reading, while zonal location is not. Inexperienced radiologists have a significantly higher FP rate in the TZ.

中文翻译：

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PIRADS（V2）3、4和5病变中的假阳性：与读者经验和区域位置的关系。

目的探讨读者体验和区域位置对PIRADS（V2）3、4和5病变对前列腺多参数（MP）-MRI假阳性（FPs）发生的影响。材料与方法这项回顾性研究包括139例在2014年至2017年间连续接受前列腺MP-MRI并经直肠超声MRI融合引导的活检的患者。一组经验不足的放射科医生对MRI检查进行了前瞻性研究（同类研究1 ； 54位患者）和经验丰富的放射科医生（第二组； 85位患者）。进行多变量logistic回归分析，以确定放射科医生的经验和区域位置与FP读数的关联。FP率是由经验不足和经验丰富的放射科医生根据区域位置进行比较的，使用卡方（χ2）检验。结果共检测到139例患者的168个病变。患者年龄中位数为68岁（四分位间距（IQR）62.5-73），整个患者队列的PSA中位数为10.9 ng / mL（IQR 7.6-15.9）。根据多变量logistic回归分析，放射科医生的经验不足很明显（P = 0.044，优势比1.927，95％置信区间[CI] 1.017-3.651），并且与FP读数独立相关，而区域位置则没有（P = 0.202，比值比为1.444，95％CI为0.820-2.539）。在过渡区（TZ），经验不足的放射科医生的FP率为59％（17/29），显着高于经验丰富的放射科医生的33％（13/40）（χ2P= 0.033）。结论放射科医生的经验不足与FP读数显着且独立相关，而区域位置则没有。