OBJECTIVE To determine the difference of serum levels of 10 adipokines (apelin, chemerin, fatty acid-binding protein-4, fibroblast growth factor-21, monocyte chemoattractant protein-1, nesfatin-1, omentin-1, resistin, vaspin, and visfatin) among women with gestational diabetes and healthy pregnant controls. MATERIALS AND METHODS Literature search was conducted using the Medline (1966-2018), Scopus (2004-2018), Cochrane Central Register of Controlled Trials (CENTRAL) (1999-2018), Clinicaltrials.gov (2008-2018) and Google Scholar (2004-2018) databases, along with the reference list of the included studies. RESULTS Ninety-one studies were included in the present review, with a total number of 11,074 pregnant women. A meta-analysis was not conducted due to the high inter-study heterogeneity. Current evidence suggests that fatty acid-binding protein-4 levels are significantly increased in pregnancies complicated with gestational diabetes, while no association of serum apelin and monocyte chemoattractant protein-1 with the disease can be supported. Data regarding the rest adipokines are conflicting, since the available studies did not unanimously indicate a significant change of their levels in gestational diabetes. CONCLUSIONS The findings of the present systematic review suggest the promising role of fatty acid-binding protein-4 in the prediction of gestational diabetes, while inconsistent evidence exists regarding the rest novel adipokines. Future cohorts are needed to assess their predictive efficacy and fully elucidate their contribution in the disease.

中文翻译：

---

妊娠糖尿病患者血清脂联素水平：系统评价。

目的确定10种脂肪因子（apelin，chemerin，脂肪酸结合蛋白-4，成纤维细胞生长因子-21，单核细胞趋化蛋白-1，nesfatin-1，omentin-1，抵抗素，vaspin和visfatin）的血清水平差异）患有妊娠糖尿病和健康孕妇的妇女。材料和方法文献检索使用Medline（1966-2018），Scopus（2004-2018），Cochrane对照试验中央登记册（CENTRAL）（1999-2018），Clinicaltrials.gov（2008-2018）和Google Scholar（ （2004-2018）数据库，以及纳入研究的参考文献清单。结果本评价纳入了91项研究，总共11 074名孕妇。由于研究间的异质性较高，因此未进行荟萃分析。目前的证据表明，在妊娠合并妊娠糖尿病的孕妇中，脂肪酸结合蛋白4的水平显着升高，而血清apelin和单核细胞趋化蛋白1与疾病的关联却无法得到支持。有关其余脂肪因子的数据相互矛盾，因为现有研究并未一致表明它们在妊娠糖尿病中的水平发生了显着变化。结论本系统综述的结果表明，脂肪酸结合蛋白4在妊娠糖尿病的预测中有望发挥作用，而有关其余新型脂肪因子的证据却不一致。需要未来的队列来评估其预测疗效并充分阐明其在疾病中的作用。