Mouse models of medulloblastoma have proven to be instrumental in understanding disease mechanisms, particularly the role of epigenetic and molecular drivers, and establishing appropriate preclinical pipelines. To date, our research community has developed murine models for all four groups of medulloblastoma, each of which will be critical for the identification and development of new therapeutic approaches. Approaches to modeling medulloblastoma range from genetic engineering with CRISPR/Cas9 or in utero electroporation, to orthotopic and patient-derived orthotopic xenograft systems. Each approach or model presents unique advantages that have ultimately contributed to an appreciation of medulloblastoma heterogeneity and the clinical obstacles that exist for this patient population.

中文翻译：

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模拟小儿髓母细胞瘤。

髓母细胞瘤小鼠模型已被证明有助于了解疾病机制，特别是表观遗传和分子驱动因素的作用，以及建立适当的临床前管道。迄今为止，我们的研究团体已经为所有四组髓母细胞瘤开发了小鼠模型，每一种模型对于识别和开发新的治疗方法都至关重要。髓母细胞瘤建模的方法包括使用 CRISPR/Cas9 或子宫内电穿孔的基因工程，以及原位和源自患者的原位异种移植系统。每种方法或模型都具有独特的优势，最终有助于了解髓母细胞瘤的异质性以及该患者群体存在的临床障碍。