The utilization of stem cells as novel carriers to target tissues or organs of interest is a challenging task in delivery system. The composite cellular delivery with diverse signalling molecules as therapeutics increases stem cell capability and possesses the promising potential to augment, modify or commence localized or systemic restoration for vital applications in regenerative medicine. The inherent potential of stem cells to immigrate and reside at wounded site facilitates transportation of genes, polypeptides or nanosized molecules. Liposomes are micro- to nano-lipidic vesicles formed in aqueous solutions to encapsulate complex hydrophilic and lipophilic chemical substances. Moreover, these novel nanocarriers provide safer and efficient delivery of bioactives together with their potential applications in vaccine production, cosmeceuticals, imaging and diagnostic purpose. Tissue engineering promotes rejuvenation process and involves the synchronized utilization of cells with 3D bio-material scaffolds to fabricate living structures. This strategy requires regulated stimulus of cultured cells through combined mechanical signals and bioactive agents. This review highlights and summarizes the mechanism involved in stem cell migration, strategies to enhance homing, safety and efficacy studies of stem cells in various disease models and discusses the potential role of liposomes in prolonged and localized delivery of bioactives for regenerative medicines and tissue engineering techniques.

Role of PEGylated liposomes in cancer stem cell therapy

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基于脂质体的干细胞在多模式癌症治疗中的作用。

利用干细胞作为新型载体靶向目标组织或器官是递送系统中的一项艰巨任务。具有多种信号分子作为治疗剂的复合细胞递送可增强干细胞能力，并具有扩大，修饰或开始局部或全身恢复的潜力，可用于再生医学。干细胞固有的潜在迁移能力并位于受伤部位，这有利于基因，多肽或纳米分子的转运。脂质体是在水溶液中形成的微囊至纳米脂质囊泡，用于包裹复杂的亲水性和亲脂性化学物质。此外，这些新型纳米载体可更安全有效地递送生物活性物质，并将其潜在地应用于疫苗生产，药妆，成像和诊断目的。组织工程促进了复兴过程，并涉及利用3D生物材料支架同步利用细胞来制造生物结构。该策略需要通过结合的机械信号和生物活性剂来调节培养细胞的刺激。这篇综述重点总结了干细胞迁移的机制，在各种疾病模型中增强干细胞归巢，安全性和功效研究的策略，并讨论了脂质体在再生药物和组织工程技术的生物活性成分的长期和局部递送中的潜在作用。 。该策略需要通过组合的机械信号和生物活性剂来调节培养细胞的刺激。这篇综述重点总结了干细胞迁移的机制，在各种疾病模型中增强干细胞归巢，安全性和功效研究的策略，并讨论了脂质体在再生药物和组织工程技术的生物活性成分的长期和局部递送中的潜在作用。 。该策略需要通过结合的机械信号和生物活性剂来调节培养细胞的刺激。这篇综述重点总结了干细胞迁移的机制，在各种疾病模型中增强干细胞归巢，安全性和功效研究的策略，并讨论了脂质体在再生药物和组织工程技术的生物活性成分的长期和局部递送中的潜在作用。 。

聚乙二醇化脂质体在癌症干细胞治疗中的作用