PURPOSE There are known associations between cardiometabolic risk factors and polypharmacy; however, there is no evidence about how polypharmacy among adults with cardiometabolic risk factors impacts their health-related quality of life (HRQoL). The main objective of this study was to assess the association between polypharmacy and HRQoL among adults with cardiometabolic risk factors living in the USA. METHODS Individuals age ≥ 18 years with at least one of the three cardiometabolic risk factors (diabetes, hyperlipidemia, and hypertension) were identified from the Medical Expenditure Panel Survey 2015 data. We defined polypharmacy as use of at least five classes of prescription medications. Physical component summary (PCS) and mental component summary (MCS) were obtained from the 12-item Short-Form Health Survey version 2 to measure HRQoL. We conducted adjusted ordinary least-square regressions to determine the association between polypharmacy and HRQoL. RESULTS We identified 7621 (weighted N = 80 million) adults with at least one cardiometabolic risk factors of whom 46.9% reported polypharmacy. Polypharmacy was noted in 29.7% of those with hypertension, whereas 82.4% of those with all the three cardiometabolic risk factors had polypharmacy. The unadjusted mean PCS and MCS scores for those with polypharmacy were lower than those without polypharmacy. In the multivariable regressions, we found that adults with polypharmacy had significantly lower PCS scores (β = - 4.27, p < 0.0001) compared to those without polypharmacy, while the MCS scores between those with and without polypharmacy were no longer significantly different. CONCLUSION Surveillance of use of concurrent prescription medications is warranted so as to improve physical functioning in this vulnerable group.

中文翻译：

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患有心脏代谢危险因素的美国成年人中，多药与健康相关的生活质量之间的关联。

目的已知心脏代谢危险因素与多药之间的关联。但是，没有证据表明患有心脏代谢危险因素的成年人中的多药治疗如何影响他们与健康相关的生活质量（HRQoL）。这项研究的主要目的是评估居住在美国的患有心脏代谢危险因素的成年人中，多药和HRQoL之间的关联。方法从2015年医疗支出小组调查数据中识别出年龄≥18岁且具有三种心血管代谢危险因素（糖尿病，高脂血症和高血压）中至少一种的个体。我们将多元药店定义为至少使用五种处方药。身体成分摘要（PCS）和心理成分摘要（MCS）从12个项目的简短健康调查版本2中获得，以测量HRQoL。我们进行了调整后的普通最小二乘回归，以确定多元药房与HRQoL之间的关联。结果我们确定了7621名（加权N = 8000万）成年人，其中至少有一种心脏代谢危险因素，其中46.9％的人报告了多药治疗。患有高血压的人中有29.7％患有多药治疗，而具有所有三种心血管危险因素的人中有82.4％具有多药治疗。拥有多药店者的未经调整的平均PCS和MCS得分低于没有多药店者。在多变量回归中，我们发现，与没有多药房的成年人相比，有多药房的成年人的PCS得分明显降低（β=-4.27，p <0.0001），而有和没有多药房的成年人之间的MCS得分不再显着不同。