Autophagy is a tightly-regulated multi-step process involving the lysosomal degradation of proteins and cytoplasmic organelles. Central to this process is the formation of the autophagosome, a double membrane-bound vesicle, which is fuse with lysosomes or endosomes, and then deliver its cytoplasmic cargo to the lysosomes. Here, we summarize the recent process of autophagy, focusing on protein molecules, their complexes, and its essential roles of autophagy in various phases. Emerging evidence has revealed that miRNAs, lncRNAs, and circRNAs play an indispensable role in autophagy regulation by modulating targeting gene expression. This review we will summarize the main features of ncRNAs and point to gaps in our current knowledge of the connection between ncRNAs and autophagy, as well as their potential utilization in various disease phenotypes. Also, we highlight recent advances in ncRNAs and autophagy-associated protein interaction and how they regulate the autophagy process.

自噬是一个严格调控的多步骤过程，涉及蛋白质和细胞质细胞器的溶酶体降解。该过程的核心是自噬体的形成，即双膜结合的囊泡，与溶酶体或内体融合，然后将其细胞质载运至溶酶体。在这里，我们总结了自噬的最新过程，重点是蛋白质分子，它们的复合物以及自噬在各个阶段的重要作用。新兴证据表明，miRNA，lncRNA和circRNA通过调节靶向基因表达在自噬调节中起着不可或缺的作用。本文将概述ncRNA的主要特征，并指出我们目前对ncRNA与自噬之间的联系以及它们在各种疾病表型中的潜在利用的了解中的空白。