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Phytochemistry and pharmacological activities of the genus Rhynchosia: a comprehensive review
Planta ( IF 3.6 ) Pub Date : 2019-11-27 , DOI: 10.1007/s00425-019-03311-2
Aluru Rammohan 1, 2 , Guda Mallikarjuna Reddy 1 , Baki Vijaya Bhaskar 3 , Duvvuru Gunasekar 2 , Grigory V Zyryanov 1, 4
Affiliation  

The genus Rhynchosia is a rich source of natural compounds especially flavonoids and prenylated isoflavonoids. Further experimental studies on Rhynchosia members may be result new and novel secondary metabolites with potent biological activities. Traditionally, medicinal plants have played a significant role on human life since ancient days. At present, natural compounds are the major source for the modern drug discovery owing to their therapeutic selectivity, minutest of side effects, inexpensive source and serve as lead molecules for the discovery of new drugs. Rhynchosia species (Fabaceae) are extensively circulated throughout the tropical and subtropical areas around the world. A few plants of this genus were used in traditional medicine for the treatment of various ailments such as antibacterial, antidiabetic, abortifacients, healing of wounds, hepatoprotective, remedial of boils, rheumatic pains and skin infections. The present review compiles traditional uses, isolated chemical compounds and pharmacological activities of Rhynchosia species. So far, in total, seventy-seven compounds were isolated from the genus Rhynchosia, including flavonoids, isoflavonoids, flavan-3-ols, xanthones, biphenyls, simple polyphenols and sterols. It is interesting to note that the genus Rhynchosia is a rich source of C-glycosylflavonoids and prenylated isoflavonoids. Further, phytochemical and pharmacological studies on this genus are required since only few species have been investigated so far.

中文翻译:

Rhynchosia属的植物化学和药理活性:综合综述

Rhynchosia 属富含天然化合物,尤其是类黄酮和异黄酮异黄酮。对 Rhynchosia 成员的进一步实验研究可能会产生具有强大生物活性的新的和新颖的次生代谢物。传统上,药用植物自古以来就在人类生活中发挥着重要作用。目前,天然化合物因其治疗选择性、副作用最小、来源廉价和作为新药发现的先导分子而成为现代药物发现的主要来源。Rhynchosia 物种(豆科)广泛分布于世界各地的热带和亚热带地区。该属的一些植物被用于传统医学中,用于治疗各种疾病,如抗菌、抗糖尿病、堕胎药、伤口愈合,保肝,治疗疖子,风湿痛和皮肤感染。本综述汇编了 Rhynchosia 物种的传统用途、分离的化合物和药理活性。到目前为止,从Rhynchosia属中总共分离出77种化合物,包括类黄酮、异黄酮、黄烷-3-醇、氧杂蒽酮、联苯、简单多酚和甾醇。有趣的是,Rhynchosia 属富含 C-糖基类黄酮和异戊二烯化异黄酮。此外,由于迄今为止只研究了少数物种,因此需要对该属进行植物化学和药理学研究。Rhynchosia 物种的分离化合物和药理活性。到目前为止,从Rhynchosia属中总共分离出77种化合物,包括类黄酮、异黄酮、黄烷-3-醇、氧杂蒽酮、联苯、简单多酚和甾醇。有趣的是,Rhynchosia 属富含 C-糖基类黄酮和异戊二烯化异黄酮。此外,由于迄今为止只研究了少数物种,因此需要对该属进行植物化学和药理学研究。Rhynchosia 物种的分离化合物和药理活性。到目前为止,从Rhynchosia属中总共分离出77种化合物,包括类黄酮、异黄酮、黄烷-3-醇、氧杂蒽酮、联苯、简单多酚和甾醇。有趣的是,Rhynchosia 属富含 C-糖基类黄酮和异戊二烯化异黄酮。此外,由于迄今为止只研究了少数物种,因此需要对该属进行植物化学和药理学研究。
更新日期:2019-11-27
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