A controlled clinical trial was carried out to assess the mortality and repellency of a new topical combination of fipronil-permethrin (Effitix® Virbac, Mexico) against Rhodnius prolixus in dogs. Ten medium-size dogs (10-15 kg) with short hair were used. The dogs were exposed to 8 adult triatomines once weekly for 7 weeks. On the control day (D0), the dogs were exposed to the insects without treatment. On D7, the dogs were immediately treated with a spot-on 2.2 ml pipette containing 134 mg of fipronil and 1200 mg permethrin after exposure to the insects. The dose was repeated after 4 weeks following the manufacturer's instructions. Repellency at D0 was, 0 % and the insects had a high blood content. After 12 h post-contact, repellency was 86.3 % and slowly decrease though D21 and D28. On D7, none of the insects survived after 3 h of feeding on the treated dogs. On D14, D35 and D42, all insects died within 12 h post-feeding, whereas no mortality was observed in the control D0 (P < 0.05). The results of this study indicated that administration of the product following the manufacturer's instructions was efficacious at inducing rapid mortality of R. prolixus and therefore could be useful to prevent the transmission of American trypanosomiasis in dogs.

中文翻译：

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氟虫腈-苄氯菊酯局部联合用药对犬罗非鱼的功效。

进行了一项对照临床试验，以评估一种新的局部用氟虫腈-苄氯菊酯组合（Effitix®Virbac，墨西哥）对狗中的Rhodnius prolixus的死亡率和驱避性。使用十只短毛中型犬（10-15公斤）。每周一次将这些狗暴露于8种成年的三氢嘧啶中，持续7周。在对照日（D0），将狗未经处理地暴露于昆虫。在第7天，暴露于昆虫后，立即用2.2 ml吸管对犬进行处理，该吸管上装有134 mg氟虫腈和1200 mg氯菊酯。按照制造商的说明在4周后重复剂量。D0的驱避度为0％，昆虫的血液含量很高。接触后12小时后，驱避度为86.3％，通过D21和D28逐渐降低。在D7上，喂食经处理的狗3小时后，没有昆虫存活。在D14，D35和D42上，所有昆虫在喂食后12小时内死亡，而在对照D0中未观察到死亡率（P <0.05）。这项研究的结果表明，按照制造商的说明管理产品可有效诱导Prolixus快速死亡，因此可用于预防美国锥虫病在狗中的传播。