The central nervous system (CNS) is comprised by an elaborate neural network that is under constant surveillance by tissue-intrinsic factors for maintenance of its homeostasis. Invading pathogens or sterile injuries might compromise vitally the CNS integrity and function. A prompt anti-inflammatory response is therefore essential to contain and repair the local tissue damage. Although the origin of the insults might be different, the principles of tissue backlashes, however, share striking similarities. CNS-resident cells, such as microglia and astrocytes, together with peripheral immune cells orchestrate an array of events that aim to functional restoration. If the acute inflammatory event remains unresolved, it becomes toxic leading to progressive CNS degeneration. Therefore, the cellular, molecular, and biochemical processes that regulate inflammation need to be on a fine balance with the intrinsic CNS repair mechanisms that influence tissue healing. The purpose of this review is to highlight aspects that facilitate the resolution of CNS inflammation, promote tissue repair, and functional recovery after acute injury and infection that could potentially contribute as therapeutic interventions.

中文翻译：

---

解决神经炎症：机制和潜在的治疗选择。

中枢神经系统（CNS）由复杂的神经网络组成，该神经网络一直受到组织内在因子的持续监视以维持其体内平衡。入侵的病原体或无菌损伤可能会严重损害CNS的完整性和功能。因此，迅速的抗炎反应对于遏制和修复局部组织损伤至关重要。尽管侮辱的起源可能有所不同，但是组织抵制的原理却有着惊人的相似之处。CNS驻留细胞（例如小胶质细胞和星形胶质细胞）与周围免疫细胞一起编排了一系列旨在功能恢复的事件。如果急性炎症事件仍未解决，它将变成有毒物质，导致进行性中枢神经系统变性。因此，细胞，分子，调节炎症的生化过程与影响组织愈合的内在中枢神经系统修复机制必须处于良好的平衡。这篇综述的目的是着重强调促进中枢神经系统炎症缓解，促进组织修复以及急性损伤和感染后功能恢复的方面，这些方面可能会作为治疗性干预措施。