The production of biopharmaceuticals in plant-based systems had faced several challenges that hampered broader adoption of this technology. In recent years, various plant production hosts have been improved by genetic engineering approaches to overcome obstacles with regard to post-translational modifications and integrity of target proteins. Together with optimized extraction and purification processes, those advances have put plant molecular farming in a more competitive position compared to established production systems. Certain biopharmaceuticals can be derived from plant systems with unique desired properties, qualifying them as biobetters.

中文翻译：

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在分子农业中优化产品质量。

在基于植物的系统中生产生物药品面临着若干挑战，这些挑战阻碍了该技术的广泛采用。近年来，已经通过基因工程方法改善了各种植物生产宿主，以克服翻译后修饰和靶蛋白完整性方面的障碍。与已建立的生产系统相比，这些进步与优化的提取和纯化过程一起，使植物分子农业处于更具竞争优势的地位。某些生物药物可以衍生自具有独特所需特性的植物系统，从而使它们成为生物制剂。