Frontal infarcts can produce cognitive impairments that affect an individual’s ability to function in everyday life. However, the precise types of deficits, and their underlying mechanisms, are not well-understood. Here we used a prefrontal photothrombotic stroke model in C57BL/6J mice to characterise specific cognitive changes that occur in the 6 weeks post-stroke. Behavioural experiments were paired with in vivo electrophysiology to assess whether changes in oscillatory communication between the prefrontal cortex (PFC) and the hippocampus (HPC) mirrored any observed behavioural changes. We found that mice in the stroke group exhibited a delayed onset impairment in tasks of spatial working memory (object location recognition and Y-maze) and that this correlated with reduced PFC–HPC theta band coherence (5–12 Hz) during the task. In the open field, mice in the stroke group exhibited hyperactivity as compared to controls, and stroke animals also exhibited significantly higher beta band activity (13–30 Hz) in the PFC and the HPC. Taken together our results suggest that infarcts in the PFC result in PFC–HPC oscillatory communication changes in the theta and beta bands, correlating with altered performance in spatial memory and open field tasks respectively. Of particular interest, early open field changes in PFC beta band power post-stroke correlated to later-stage spatial memory impairments, highlighting this as a potential biomarker for detecting when spatial memory impairments are likely to occur.

中文翻译：

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小鼠内侧前额中风后海马前额叶动力学改变。

额叶梗塞可产生认知障碍，影响个人在日常生活中的功能。但是，对赤字的确切类型及其潜在机制并没有很好的理解。在这里，我们在C57BL / 6 J中使用了额叶前血栓性中风模型小鼠的特征是中风后6周内发生的特定认知变化。行为实验与体内电生理学相结合，以评估前额叶皮层（PFC）和海马（HPC）之间的振荡通讯变化是否反映了任何观察到的行为变化。我们发现，中风组的小鼠在空间工作记忆任务（对象位置识别和Y迷宫）中表现出延迟发作损伤，并且这与任务过程中PFC-HPC theta带相干性降低（5-12 Hz）相关。在开阔的田野中，与对照组相比，中风组小鼠表现出过度活跃，中风动物在PFC和HPC中也表现出明显更高的β谱带活动（13–30 Hz）。总之，我们的结果表明，PFC中的梗塞导致theta和beta波段中PFC–HPC的振荡通信发生变化，分别与空间记忆和开放领域任务的性能变化相关。特别令人感兴趣的是，卒中后PFCβ带功率的早期开放视野变化与后期空间记忆损害相关，这突出显示了它是一种潜在的生物标记，可用于检测何时可能发生空间记忆损害。