Ulcerative colitis designates an idiopathic chronic inflammatory bowel disease leading to bloody diarrhea and inflammatory alterations mostly restricted to the large intestine. Many studies continue to unravel important aspects of its etiopathogenesis, and recent pharmaceutical developments broaden the arsenal of therapeutic opportunity. In this review, we delve into the cellular and molecular determinants of successful resolution of ulcerative colitis, describing novel insights in each of the phases of mucosal healing starting from damaging insults to the mucosa, epithelial restitution, and its adaption to inflammation as well as lymphocyte-driven maintenance and resolution of chronic inflammation. Additionally, molecular switches from inflammation to resolution are explored, paving the way for future avenues to resolve ulcerative colitis.

中文翻译：

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解决溃疡性结肠炎。

溃疡性结肠炎是指一种特发性慢性炎症性肠病，导致血液性腹泻和炎症性改变，大部分局限于大肠。许多研究继续揭示其发病机理的重要方面，并且最近的药物开发拓宽了治疗机会的范围。在这篇综述中，我们深入研究了成功解决溃疡性结肠炎的细胞和分子决定因素，描述了从破坏性损伤粘膜，上皮恢复原状及其对炎症和淋巴细胞的适应性开始的各个阶段的粘膜愈合的新见解。驱动的维护和慢性炎症的解决。此外，探索了从炎症到消退的分子转换，为将来解决溃疡性结肠炎的途径铺平了道路。