PURPOSE This study aimed to explore the possible range of change of a single-session music intervention (SMI) on symptom clusters and neurological reactivity for women with breast cancer undergoing chemotherapy. METHODS A parallel and randomized, controlled study with repeated measures design was used. A total of 100 women with breast cancer were randomly assigned to the SMI or a control group. The outcome measurements of symptom cluster were collected using the Multidimensional Fatigue Symptom Inventory, Pittsburgh Sleep Quality Index, the Hospital Anxiety and Depression Scale, and the neurological reactivity with heart rate variability at four time points: before commencement of the intervention (T0), immediately afterward (T1), 1 week later (T2), and 3 weeks after the intervention (T3). RESULTS Of the 50 women in each group, 46 in the SMI and 48 in the control group completed the post-test at T3. Multivariate analysis of variance indicated that the SMI group had a medium effect in change of symptom clusters compared to the control group at T2. Moreover, after adjusting for baseline between normal and higher levels of sympathetic tone activity, significant differences existed in fatigue and depression at T2 and sleep disturbance at T3. CONCLUSIONS A single-session music intervention can be effectively used to reduce symptom clusters for women with breast cancer. Targeting those who have a higher level of sympathetic tone activity is recommended.

中文翻译：

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音乐、心率变异性和症状群：一项比较研究。

目的 本研究旨在探讨单次音乐干预 (SMI) 对接受化疗的乳腺癌女性患者症状群和神经反应的可能变化范围。方法 采用重复测量设计的平行和随机对照研究。共有 100 名乳腺癌女性被随机分配到 SMI 组或对照组。使用多维疲劳症状量表、匹兹堡睡眠质量指数、医院焦虑和抑郁量表以及四个时间点的心率变异性神经反应性收集症状群的结果测量：干预开始前 (T0)，立即干预后（T1）、干预后 1 周（T2）和干预后 3 周（T3）。结果 在每组的 50 名女性中，SMI 中的 46 人和对照组中的 48 人在 T3 完成了后测。多变量方差分析表明，在 T2 时，与对照组相比，SMI 组对症状群变化的影响中等。此外，在对正常和较高水平的交感神经活动之间的基线进行调整后，T2 时的疲劳和抑郁以及 T3 时的睡眠障碍存在显着差异。结论 单次音乐干预可以有效地减少乳腺癌女性的症状群。建议针对那些具有较高交感神经活性的人。在对正常和较高交感神经活动水平之间的基线进行调整后，T2 时的疲劳和抑郁以及 T3 时的睡眠障碍存在显着差异。结论 单次音乐干预可以有效地减少乳腺癌女性的症状群。建议针对那些具有较高交感神经活性的人。在对正常和较高交感神经活动水平之间的基线进行调整后，T2 时的疲劳和抑郁以及 T3 时的睡眠障碍存在显着差异。结论 单次音乐干预可以有效地减少乳腺癌女性的症状群。建议针对那些具有较高交感神经活性的人。