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Comprehensive Review on Graphene Oxide for Use in Drug Delivery System.
Current Medicinal Chemistry ( IF 3.5 ) Pub Date : 2020-06-30 , DOI: 10.2174/13816128256661902011296290
Muhammad Daniyal 1 , Bin Liu 2 , Wei Wang 1
Affiliation  

Motivated by the accomplishment of carbon nanotubes (CNTs), graphene and graphene oxide (GO) has been widely investigated in the previous studies as an innovative medication nanocarrier for the loading of a variety of therapeutics as well as anti-cancer medications, poor dissolvable medications, antibiotics, antibodies, peptides, DNA, RNA and genes. Graphene provides the ultra-high drug-loading efficiency due to the wide surface area. Graphene and graphene oxide have been widely investigated for biomedical applications due to their exceptional qualities: twodimensional planar structure, wide surface area, chemical and mechanical constancy, sublime conductivity and excellent biocompatibility. Due to these unique qualities, GO applications provide advanced drug transports frameworks and transports of a broad range of therapeutics. In this review, we discussed the latest advances and improvements in the uses of graphene and GO for drug transport and nanomedicine. Initially, we have described what is graphene and graphene oxide. After that, we discussed the qualities of GO as a drug carrier, utilization of GO in drug transport applications, targeted drug transport, transport of anticancer medications, chemical control medicine releasee, co-transport of different medications, comparison of GO with CNTs, nano-graphene for drug transport and at last, we have discussed the graphene toxicity. Finally, we draw a conclusion of current expansion and the potential outlook for the future.



中文翻译:

氧化石墨烯在药物输送系统中的应用综述。

由于碳纳米管(CNT)的成就,石墨烯和氧化石墨烯(GO)在以前的研究中已被广泛研究,作为一种创新的药物纳米载体,可装载多种治疗药物以及抗癌药物,难溶性药物,抗生素,抗体,肽,DNA,RNA和基因。石墨烯具有宽表面积,可提供超高的载药效率。石墨烯和氧化石墨烯因其优异的品质而被广泛研究用于生物医学应用:二维平面结构,宽表面积,化学和机械恒定性,高电导率以及出色的生物相容性。由于这些独特的品质,GO应用程序提供了先进的药物运输框架和各种治疗剂的运输。在这篇评论中 我们讨论了石墨烯和GO在药物运输和纳米药物中的最新使用进展和改进。最初,我们描述了什么是石墨烯和氧化石墨烯。之后,我们讨论了GO作为药物载体的质量,GO在药物运输应用中的利用,靶向药物运输,抗癌药物的运输,化学控制药物的释放,不同药物的共同运输,GO与CNT的比较,纳米-石墨烯用于药物运输,最后,我们讨论了石墨烯的毒性。最后,我们得出了当前扩张的结论以及未来的潜在前景。我们讨论了GO作为药物载体的质量,GO在药物运输应用中的利用,靶向药物运输,抗癌药物的运输,化学控制药物的释放,不同药物的共同运输,GO与CNT的比较,纳米石墨烯的用途。药物运输,最后,我们讨论了石墨烯的毒性。最后,我们得出了当前扩张的结论以及未来的潜在前景。我们讨论了GO作为药物载体的质量,GO在药物运输应用中的利用,靶向药物运输,抗癌药物的运输,化学控制药物的释放,不同药物的共同运输,GO与CNT的比较,纳米石墨烯的用途。药物运输,最后,我们讨论了石墨烯的毒性。最后,我们得出了当前扩张的结论以及未来的潜在前景。

更新日期:2020-06-30
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