SummaryType III intermediate filament (IF) proteins assemble into cytoplasmic homopolymeric and heteropolymeric filaments with other type III and some type IV IFs. These highly dynamic structures form an integral component of the cytoskeleton of muscle, brain, and mesenchymal cells. Here, we review the current ideas on the role of type III IFs in health and disease. It turns out that they not only offer resilience to mechanical strains, but, most importantly, they facilitate very efficiently the integration of cell structure and function, thus providing the necessary scaffolds for optimal cellular responses upon biochemical stresses and protecting against cell death, disease, and aging.

中文翻译：

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III型中间丝结蛋白，胶质纤维酸性蛋白（GFAP），波形蛋白和外周蛋白。

总结III型中间丝（IF）蛋白与其他III型和某些IV型IF组装成胞质均聚物和杂聚物丝。这些高度动态的结构形成了肌肉，大脑和间充质细胞细胞骨架的组成部分。在这里，我们回顾了有关III型IF在健康和疾病中作用的最新观点。事实证明，它们不仅可以抵抗机械应力，而且最重要的是，它们可以非常有效地促进细胞结构和功能的整合，从而为必要的支架提供了必要的支架，以应对生化应激时的最佳细胞反应并防止细胞死亡，疾病，和老化。