Irritable bowel syndrome (IBS) is associated with diverse pathophysiologic mechanisms. These mechanisms include increased abnormal colonic motility or transit, intestinal or colorectal sensation, increased colonic bile acid concentration, and superficial colonic mucosal inflammation, as well as epithelial barrier dysfunction, neurohormonal up-regulation, and activation of secretory processes in the epithelial layer. Novel approaches to treatment include lifestyle modification, changes in diet, probiotics, and pharmacotherapy directed to the motility, sensation, and intraluminal milieu of patients with IBS. Despite recent advances, there is a need for development of new treatments to relieve pain in IBS without deleterious central or other adverse effects.

中文翻译：

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肠易激综合症的管理选择。

肠易激综合征（IBS）与多种病理生理机制有关。这些机制包括异常结肠运动或转运，肠道或结肠直肠感觉增加，结肠胆汁酸浓度增加和结肠浅表粘膜炎症，以及上皮屏障功能障碍，神经激素上调和上皮层分泌过程的激活。新的治疗方法包括改变生活方式，改变饮食，益生菌和针对IBS患者运动，感觉和管腔内环境的药物疗法。尽管有最近的进展，但仍需要开发新的疗法来减轻IBS的疼痛而又无有害的中枢或其他不利影响。