I worked almost exclusively on nucleic acids and gene expression from the age of 19 as an undergraduate until the age of 38 as an associate professor. Mentors featured prominently in my choice of paths. My friendship with influential Brandeis colleagues then persuaded me that genetics was an important tool for studying gene expression, and I switched my experimental organism to yeast for this reason. Several years later, friendship also played a prominent role in my beginning work on circadian rhythms. As luck would have it, gene expression as well as genetics turned out to be important for circadian timekeeping. As a consequence, background and training put my laboratory in an excellent position to contribute to this aspect of the circadian problem. The moral of the story is, as in real estate, "location, location, location."

中文翻译：

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50年的个人旅程：位置，基因表达和昼夜节律。

从19岁的本科生到38岁的副教授，我几乎专门从事核酸和基因表达的研究。在我选择的路径中，导师非常突出。然后，我与有影响力的Brandeis同事的友谊说服了我，遗传学是研究基因表达的重要工具，因此我将实验性生物改为酵母。几年后，友谊在我从事昼夜节律的工作中也发挥了重要作用。幸运的是，基因表达和遗传学对于昼夜节律至关重要。因此，背景和培训使我的实验室处于有利位置，可以为昼夜节律问题的这一方面做出贡献。就像在房地产行业一样，这个故事的寓意是“位置，位置，位置”。