The high incidence of pertussis in vaccinated adolescents suggests the failing of immune memory. We argue that acellular pertussis vaccines generate memory cells that are effectively reactivated by boosters better than by Bordetella pertussis exposure. We propose that there are two main causes. One is the induction of vaccine-specific immunity rather than pathogen-specific immunity. The second is that strictly mucosal infections such as B. pertussis poorly reactivate memory B and T cells residing deep in lymph nodes or tissues. Developing new vaccines for infants or adolescents will be immunologically and economically challenging. Let us hope that maternal and infant immunization, to date the most effective strategies against pertussis death, will remain so.

中文翻译：

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百日咳疫苗免疫有什么问题？诱导和恢复疫苗特异性免疫。


接种疫苗的青少年百日咳发病率较高，表明免疫记忆能力下降。我们认为，无细胞百日咳疫苗产生的记忆细胞可以通过加强剂比接触百日咳博德特氏菌更好地有效地重新激活。我们认为有两个主要原因。一是诱导疫苗特异性免疫而不是病原体特异性免疫。其次，严格的粘膜感染（例如百日咳博德特氏菌）很难重新激活位于淋巴结或组织深处的记忆 B 细胞和 T 细胞。为婴儿或青少年开发新疫苗在免疫学和经济上都具有挑战性。让我们希望，迄今为止最有效的预防百日咳死亡策略的孕产妇和婴儿免疫接种将继续如此。