Intracranial germ cell tumors of the central nervous system are rare. Mixed type germ cell tumors with yolk sac component account for 12% and pure yolk sac tumors for 2%. We report the clinicocytopathological and immunocytopathological findings of a 13.5 year old male with mixed germ cell tumor including yolk sac elements. This case was diagnosed by cytology and confirmed by immunocytology in cerebrospinal fluid smears. MRI findings favored malignancy such as lymphoma and germinoma .As beta-ΗCG was elevated in serum and cerebrospinal fluid, lymphoma was ruled out and histological confirmation of the diagnosis of germinoma was not necessary. The presence of AFP positive, βHCG positive, c-kit positive, and PLAP positive cells, established the diagnosis.

中文翻译：

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脑脊液中卵黄囊成分对原发性松果体生殖细胞肿瘤的细胞学诊断。

中枢神经系统的颅内生殖细胞肿瘤很少见。具有卵黄囊成分的混合型生殖细胞肿瘤占12％，而纯卵黄囊肿瘤占2％。我们报告了13.5岁男性混合生殖细胞肿瘤包括卵黄囊元素的临床细胞病理学和免疫细胞病理学发现。该病例经细胞学检查确诊，并经免疫细胞学检查确诊为脑脊液涂片。MRI表现有利于恶性肿瘤，例如淋巴瘤和生殖细胞瘤。由于血清和脑脊液中β-ΗCG升高，因此排除了淋巴瘤，无需组织学确认诊断生殖细胞瘤。AFP阳性，βHCG阳性，c-kit阳性和PLAP阳性细胞的存在确定了诊断。