Visualizing regions of conserved synteny between two genomes is supported by numerous software applications. However, none of the current applications allow researchers to select genome features to display or highlight in blocks of synteny based on the annotated biological properties of the features (e.g., type, function, and/or phenotype association). To address this usability gap, we developed an interactive web-based conserved synteny browser, The Jackson Laboratory (JAX) Synteny Browser. The browser allows researchers to highlight or selectively display genome features in the reference and/or the comparison genome according to the biological attributes of the features. Although the current implementation for the browser is limited to the reference genomes for the laboratory mouse and human, the software platform is intentionally genome agnostic. The JAX Synteny Browser software can be deployed for any two genomes where genome coordinates for syntenic blocks are defined and for which biological attributes of the features in one or both genomes are available in widely used standard bioinformatics file formats. The JAX Synteny Browser is available at: http://syntenybrowser.jax.org/. The code base is available from GitHub: https://github.com/TheJacksonLaboratory/syntenybrowser and is distributed under the Creative Commons Attribution license (CC BY).

中文翻译：

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用于小鼠-人类比较基因组学的 JAX Synteny 浏览器。


许多软件应用程序支持可视化两个基因组之间的保守同线性区域。然而，当前的应用程序都不允许研究人员根据特征的注释生物学特性（例如，类型、功能和/或表型关联）来选择要在同线性块中显示或突出显示的基因组特征。为了解决这一可用性差距，我们开发了一种基于 Web 的交互式保守同线性浏览器，即杰克逊实验室 (JAX) Synteny 浏览器。该浏览器允许研究人员根据特征的生物学属性突出显示或选择性地显示参考和/或比较基因组中的基因组特征。尽管浏览器当前的实现仅限于实验室小鼠和人类的参考基因组，但该软件平台有意与基因组无关。 JAX Synteny Browser 软件可部署于任何两个基因组，其中定义了同线性块的基因组坐标，并且一个或两个基因组中的特征的生物属性可在广泛使用的标准生物信息学文件格式中获得。 JAX Synteny 浏览器位于：http://syntenybrowser.jax.org/。代码库可从 GitHub 获取：https://github.com/TheJacksonLaboratory/syntenybrowser，并根据知识共享归属许可 (CC BY) 分发。