Failure of treatment strategies against cancers is a major issue engaging many scientists to investigate the possible resistance factors. Cancer stem cells (CSCs) subvert promising therapeutic methods by developing resistant cancers. These pluripotent cells are located in individual microenvironments called cancer niche. CSCs affect the immune cells and on the flip side, the immune cells in the cancer niche influence them. Thereby, the interaction between CSCs and immune cells in cancer niche needs to be clearly studied in order to develop novel efficient methods of immune-based cancer treatment. In this article, we review literature about the suggested methods of CSC escape from immune responses and the effect of cancer niche characteristics on the ability of CSCs to develop resistant strains of cancers. Moreover, we discuss immune-mediated tumor targeting methods and bring in trials focused on CSC targeted therapies. We aim to help physicians to reach a consensus about using CSC-targeted immunotherapy methods and emerge novel immunotherapy methods through disrupting the interaction between immune cells and CSCs in the tumor microenvironment.

针对癌症的治疗策略失败是吸引许多科学家研究可能的耐药因素的主要问题。癌症干细胞（CSC）通过发展抗药性癌症而颠覆了有前途的治疗方法。这些多能细胞位于称为癌症小生境的单个微环境中。CSC影响免疫细胞，另一方面，癌症领域的免疫细胞也会影响免疫细胞。因此，需要明确研究癌位中CSC与免疫细胞之间的相互作用，以便开发基于免疫的新型有效癌症治疗方法。在本文中，我们回顾了有关从免疫应答中逃逸的CSC的建议方法以及癌症小生境特征对CSC产生抗药性菌株能力的影响的文献。此外，我们讨论了免疫介导的肿瘤靶向方法，并引入了针对CSC靶向疗法的试验。我们旨在帮助医生达成关于使用靶向CSC的免疫治疗方法的共识，并通过破坏肿瘤微环境中免疫细胞与CSC之间的相互作用来出现新的免疫治疗方法。