Mitochondria are crucial to support synaptic activity, particularly through ATP production and Ca²⁺ homeostasis. This implies that mitochondria need to be well distributed throughout the different neuronal sub‐compartments. To achieve this, a tight and precise regulation of several neuronal cytoskeleton players is necessary to transport and dock mitochondria. As post‐mitotic cells, neurons are highly dependent on mitochondrial quality control mechanisms and several cytoskeleton proteins have been implicated in mitophagy. Therefore, all of these processes are orchestrated by the crosstalk between mitochondria and the neuronal cytoskeleton to form a coordinated and tuned symphony.

中文翻译：

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排列神经元中的线粒体：以细胞骨架为导体。

线粒体对于支持突触活性至关重要，尤其是通过ATP产生和Ca ²⁺体内平衡。这意味着线粒体需要在不同的神经元小室中很好地分布。为了实现这一点，必须精确和精确地调节几个神经元细胞骨架的参与者，以运输和停泊线粒体。作为有丝分裂后细胞，神经元高度依赖于线粒体质量控制机制，并且已经有几种细胞骨架蛋白参与了线粒体吞噬。因此，所有这些过程都是通过线粒体和神经元细胞骨架之间的串扰来协调的，从而形成协调一致的交响乐。