Lipidomics links oxidized phosphatidylcholines and coronary arteritis in Kawasaki disease.,Cardiovascular Research

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Lipidomics links oxidized phosphatidylcholines and coronary arteritis in Kawasaki disease.
Cardiovascular Research ( IF 10.2 ) Pub Date : 2019-11-29 , DOI: 10.1093/cvr/cvz305
Yasutaka Nakashima ₁ , Yasunari Sakai ₁ , Yumi Mizuno ₂ , Kenji Furuno ₂ , Keiichi Hirono ₃ , Shinichi Takatsuki ₄ , Hiroyuki Suzuki ₅ , Yoshihiro Onouchi ₆ , Tohru Kobayashi ₇ , Kazuhiro Tanabe ₈ , Kenji Hamase ₉ , Tomofumi Miyamoto ₁₀ , Ryohei Aoyagi _{11,

12} , Makoto Arita _{11,

12} , Kenichiro Yamamura ₁ , Tamami Tanaka ₁ , Hisanori Nishio ₁ , Hidetoshi Takada ₁₃ , Shouichi Ohga ₁ , Toshiro Hara ₂

Affiliation

Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Kawasaki Disease Center, Fukuoka Children's Hospital, 5-1-1 Kashiiteriha, Higashi-ku, Fukuoka 813-0017, Japan.
Department of Pediatrics, Graduate School of Medicine, University of Toyama, Toyama 930-194, Japan.
Department of Pediatrics, Toho University Omori Medical Center, Tokyo 143-8540, Japan.
Department of Pediatrics, Wakayama Medical University, Wakayama 641-8509, Japan.
Department of Public Health, Chiba University Graduate School of Medicine, Chiba 260-0856, Japan.
Department of Management and Strategy, Clinical Research Center, National Center for Child Health and Development, Tokyo 157-0074, Japan.
Medical Solution Promotion Department, LSI Medience Corporation, Tokyo 101-8517, Japan.
Department of Drug Discovery and Evolution, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Department of Pharmaceutical Health Care and Sciences, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences (IMS), Tsurumi, Yokohama, Kanagawa 230-0045, Japan.
Division of Physiological Chemistry and Metabolism, Graduate School of Pharmaceutical Sciences, Keio University, Minato-ku, Tokyo 105-0011, Japan.
Department of Child Health, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.

Coronary arteritis is a life-threatening complication that may arise in the acute stage of Kawasaki disease (KD), the leading cause of systemic vasculitis in childhood. Various microorganisms and molecular pathogens have been reported to cause KD. However, little is known about the key molecules that contribute to the development of coronary arteritis in KD.

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