very high levels of a monoclonal ab that does not reflect the ab repertoire of patients with anti-NMDARe, and even less so, the abs of MPs. Second, there is no evidence that the abs of MPs are similar to those of patients with anti-NMDARe or have similar pathogenicity. One study assessing the effects of NMDAR-abs of asymptomatic persons, using high-resolution single particle imaging, showed that the abs were not pathogenic. Third, the scenario that best addresses the effects of placental transfer of NMDAR-abs from mother to fetus is provided by patients who develop anti-NMDARe during pregnancy or become pregnant soon after recovery. We reviewed our experience and that reported in the English literature (Table): (1) the neonatal mortality of children of mothers with anti-NMDARe during pregnancy was low; (2) if problems occurred, they were mainly due to obstetrical complications related to systemic symptoms of the mothers; and (3) during follow-up, most children appeared to be doing well. Thus, the findings suggest that children of mothers with anti-NMDARe do not have the high neonatal mortality or poor outcome suggested by Jurek’s model. On the other hand, the appropriate model to assess whether serum NMDAR-abs of asymptomatic mothers cause congenital neuropsychiatric disease in their children would be the use of IgG of these mothers instead of a monoclonal ab from a patient with anti-NMDARe.

中文翻译：

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回复“妊娠、NMDA受体抗体与神经精神疾病”

非常高水平的单克隆 ab 不能反映抗 NMDARe 患者的 ab 库，更不用说 MP 的 abs。其次，没有证据表明 MPs 的 abs 与抗 NMDARe 患者的 abs 相似或具有相似的致病性。一项使用高分辨率单粒子成像评估 NMDAR-abs 对无症状人员的影响的研究表明，abs 不是致病性的。第三，最能解决 NMDAR-abs 从母亲胎盘转移到胎儿的情况是由在怀孕期间产生抗 NMDARe 或在恢复后很快怀孕的患者提供的。我们回顾了我们的经验和英文文献中报道的经验（表）：（1）妊娠期间抗 NMDARe 母亲的孩子的新生儿死亡率低；(2) 如果出现问题，它们主要是由于与母亲全身症状相关的产科并发症；(3) 在随访期间，大多数儿童表现良好。因此，研究结果表明，抗 NMDARe 母亲的孩子没有 Jurek 模型所暗示的高新生儿死亡率或不良结局。另一方面，评估无症状母亲的血清 NMDAR-abs 是否会导致其子女先天性神经精神疾病的合适模型是使用这些母亲的 IgG，而不是来自抗 NMDARe 患者的单克隆 ab。研究结果表明，抗 NMDARe 母亲的孩子没有 Jurek 模型所暗示的高新生儿死亡率或不良结局。另一方面，评估无症状母亲的血清 NMDAR-abs 是否会导致其子女先天性神经精神疾病的合适模型是使用这些母亲的 IgG，而不是来自抗 NMDARe 患者的单克隆 ab。研究结果表明，抗 NMDARe 母亲的孩子没有 Jurek 模型所暗示的高新生儿死亡率或不良结局。另一方面，评估无症状母亲的血清 NMDAR-abs 是否会导致其子女先天性神经精神疾病的合适模型是使用这些母亲的 IgG，而不是来自抗 NMDARe 患者的单克隆 ab。