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Significant artefactual noise in 90Y TOF-PET imaging of low specific activity phantoms arises despite increased acquisition time.
EJNMMI Physics ( IF 4 ) Pub Date : 2019-11-28 , DOI: 10.1186/s40658-019-0259-6
Michel Hesse 1 , Stephan Walrand 1
Affiliation  

Volumes of usual PET phantoms are about four to sixfold that of a human liver. In order to avoid count rate saturation and handling of very high 90Y activity, reported TOF-PET phantom studies are performed using specific activities lower than those observed in liver radioembolization.However, due to the constant random coincidence rate induced by the natural crystal radioactivity, reduction of 90Y specific activity in TOF-PET imaging cannot be counterbalanced by increasing the acquisition time. As a result, most 90Y phantom studies reported images noisier than those obtained in whole-body 18F-FDG, and thus advised to use dedicated noise control in TOF-PET imaging post 90Y liver radioembolization.We performed acquisitions of the Jaszczak Deluxe phantom in which the hot rod insert was only partially filled with 2.6 GBq of 90Y. Standard reconstruction parameters recommended by the manufacturer for whole-body 18F-FDG PET were used.Low specific activity setups, although exactly compensated by increasing the acquisition time in order to get the same number of detected true coincidences per millilitre, were impacted by significant noise. On the other hand, specific activity and acquisition time setup similar to that used in post 90Y liver radioembolization provided image quality very close to that of whole-body 18F-FDG.This result clearly discards the use of low specific activity phantoms intended to TOF-PET reconstruction parameter optimization. Volume reduction of large phantoms can be achieved by vertically setting the phantoms or by adding Styrofoam inserts.

中文翻译:

尽管采集时间增加,但在低比活动体模的90Y TOF-PET成像中仍会出现明显的伪像噪声。

普通PET体模的体积约为人类肝脏的4至6倍。为了避免计数率饱和和处理很高的90Y活性,已报道的TOF-PET体模研究使用的比活度低于在肝脏放射栓塞中观察到的比活度。但是,由于天然晶体放射性诱发的恒定随机符合率,不能通过增加采集时间来抵消TOF-PET成像中90Y比活的降低。结果,大多数90Y幻像研究报告的图像比在全身18F-FDG中获得的图像噪声更大,因此建议在90Y肝放射性栓塞后在TOF-PET成像中使用专用的噪声控制。我们进行了Jaszczak Deluxe幻像的采集,其中热棒插件仅部分填充了90 GB的2.6 GBq。使用了制造商推荐的用于18F-FDG全身PET的标准重建参数。低比活设置虽然通过增加采集时间进行了精确补偿,但为了获得相同的每毫米检测到的真实巧合次数,却受到了明显的噪音影响。另一方面,比活度和获取时间的设置与90Y后肝脏放射性栓塞术中使用的设置相似,所提供的图像质量非常接近全身18F-FDG的图像质量。 PET重建参数优化。大型幻影的体积减小可通过垂直放置幻影或添加聚苯乙烯泡沫塑料插入物来实现。尽管可以通过增加采集时间来进行精确补偿,以便获得每毫米相同数量的检测到的真实重合,但仍受到明显噪声的影响。另一方面,比活度和获取时间的设置类似于90Y后肝脏放射栓塞所使用的设置,所提供的图像质量非常接近全身18F-FDG的图像质量。该结果显然摒弃了针对TOF-F的低比活度模型的使用。 PET重建参数优化。大型幻影的体积减小可通过垂直放置幻影或添加聚苯乙烯泡沫塑料插入物来实现。尽管可以通过增加采集时间来进行精确补偿,以便获得每毫米相同数量的检测到的真实重合,但仍受到明显噪声的影响。另一方面,比活度和获取时间的设置类似于90Y后肝脏放射栓塞所使用的设置,所提供的图像质量非常接近全身18F-FDG的图像质量。该结果显然摒弃了针对TOF-F的低比活度模型的使用。 PET重建参数优化。大型幻影的体积减小可通过垂直放置幻影或添加聚苯乙烯泡沫塑料插入物来实现。比活度和获取时间的设置类似于90年后肝脏放射栓塞所使用的设置,提供的图像质量非常接近全身18F-FDG的图像质量。大型幻影的体积减小可通过垂直放置幻影或添加聚苯乙烯泡沫塑料插入物来实现。比活度和获取时间的设置类似于90年后肝脏放射栓塞术中所使用的设置,提供的图像质量非常接近全身18F-FDG的图像质量。此结果显然放弃了用于TOF-PET重建参数优化的低比活体模的使用。大型幻影的体积减小可通过垂直放置幻影或添加聚苯乙烯泡沫塑料插入物来实现。
更新日期:2019-11-01
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