当前位置: X-MOL 学术Immunogenetics › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Nomenclature report for killer-cell immunoglobulin-like receptors (KIR) in macaque species: new genes/alleles, renaming recombinant entities and IPD-NHKIR updates.
Immunogenetics ( IF 2.9 ) Pub Date : 2019-11-29 , DOI: 10.1007/s00251-019-01135-8
Jesse Bruijnesteijn 1 , Natasja G de Groot 1 , Nel Otting 1 , Giuseppe Maccari 2, 3 , Lisbeth A Guethlein 4 , James Robinson 3, 5 , Steven G E Marsh 3, 5 , Lutz Walter 6 , David H O'Connor 7 , John A Hammond 2 , Peter Parham 4 , Ronald E Bontrop 1, 8
Affiliation  

The Killer-cell Immunoglobulin-like Receptors (KIR) are encoded by a diverse group of genes, which are characterized by allelic polymorphism, gene duplications, and recombinations, which may generate recombinant entities. The number of reported macaque KIR sequences is steadily increasing, and these data illustrate a gene system that may match or exceed the complexity of the human KIR cluster. This report lists the names of quality controlled and annotated KIR genes/alleles with all the relevant references for two different macaque species: rhesus and cynomolgus macaques. Numerous recombinant KIR genes in these species necessitate a revision of some of the earlier-published nomenclature guidelines. In addition, this report summarizes the latest information on the Immuno Polymorphism Database (IPD)-NHKIR Database, which contains annotated KIR sequences from four non-human primate species.

中文翻译:

猕猴物种中的杀伤细胞免疫球蛋白样受体(KIR)的命名报告:新基因/等位基因,重命名重组实体和IPD-NHKIR更新。

杀伤细胞免疫球蛋白样受体(KIR)由多种基因编码,这些基因的特征是等位基因多态性,基因重复和重组,这些基因可能会产生重组实体。猕猴KIR序列的报告数量在稳步增加,这些数据说明了一个可能与人类KIR簇的复杂性相匹配或超越的基因系统。该报告列出了质量控制和带注释的KIR基因/等位基因的名称,以及两个不同猕猴物种(恒河猴和食蟹猕猴)的所有相关参考。这些物种中的大量重组KIR基因需要修订一些较早出版的命名准则。此外,本报告总结了有关免疫多态性数据库(IPD)-NHKIR数据库的最新信息,
更新日期:2020-04-21
down
wechat
bug