Abstract

Selective anxiolytic fabomotizole (Afobazol®) has affinity for the Sigma-1 chaperone receptor site, quinone reductase 2 (NQO2) and MAO-A regulatory sites, and melatonin receptor type 1 (MT₁ receptor). The analysis of the effect of fabomotizole on the gene expression profile in the brain of MR (Maudsley Reactive) rats was carried out when modeling emotional stress in the open field test. A change in the expression of 14 genes was found, the results of the functional annotation of which showed that the mechanisms of action of fabomotizole may be associated with the regulation of translation of proteins (Rpl5, Rpl15, Ncl, and Ybx1), synaptic functions (Cplx2, Dlg4, Syngap1, Add1, Rab8b, Klc1, and Chn1), and cellular metabolism (Akr1d1, Bcat1, and Pkm).

中文翻译：

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在户外试验中，法莫莫唑对MR大鼠脑基因表达的影响。

摘要

选择性抗焦虑型依莫替莫唑（Afobazol®）对Sigma-1伴侣受体部位，醌还原酶2（NQO2）和MAO-A调节部位以及褪黑激素1型受体（MT ₁受体）具有亲和力。在开场试验中模拟情绪应激时，进行了法莫替唑对MR（Maudsley反应性）大鼠大脑基因表达谱的影响的分析。发现了14个基因表达的变化，其功能注释的结果表明，法莫莫唑的作用机制可能与蛋白质翻译的调控（Rpl5，Rpl15，Ncl和Ybx1），突触功能有关（Cplx2，Dlg4，Syngap1，Add1，Rab8b，Klc1和Chn1）和细胞代谢（Akr1d1，Bcat1和Pkm）。