Clinical aspects dealing with the impairment of nephrogenesis in preterm and low birth weight babies were intensely researched. In this context it was shown that quite different noxae can harm nephron formation, and that the morphological damage in the fetal kidney is rather complex. Some pathological findings show that the impairment leads to changes in developing glomeruli that are restricted to the maturation zone of the outer cortex in the fetal human kidney. Other data show also imprints on the stages of nephron anlage including the niche, the pretubular aggregate, the renal vesicle, and comma- and S-shaped bodies located in the overlying nephrogenic zone of the rodent and human kidneys. During our investigations it was noticed that the stages of nephron anlage in the fetal human kidney during the phase of late gestation have not been described in detail. To contribute, these stages were recorded along with corresponding images. The initial nephron formation in the rodent kidney served as a reference. Finally, the known imprints left by the impairment in both specimens were listed and discussed. In sum, the relatively paucity of data on nephron formation in the fetal human kidney during the late phase of gestation is a call to start with intense research so that concepts for a therapeutic prolongation of nephrogenesis can be designed.

中文翻译：

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寻找肾形成障碍留下的印记

对处理早产和低出生体重婴儿肾发生损害的临床方面进行了深入研究。在这种情况下，表明完全不同的 noxae 会损害肾单位的形成，并且胎儿肾脏的形态学损伤相当复杂。一些病理学发现表明，这种损伤导致发育中的肾小球发生变化，这些变化仅限于胎儿人肾外皮层的成熟区。其他数据还显示了肾原原细胞阶段的印记，包括生态位、管前聚集体、肾囊泡以及位于啮齿动物和人类肾脏上覆肾源区的逗号和 S 形体。在我们的调查过程中注意到，在妊娠晚期阶段，人类胎儿肾脏中肾单位原基的阶段尚未得到详细描述。为了做出贡献，这些阶段与相应的图像一起被记录下来。啮齿动物肾脏中最初的肾单位形成作为参考。最后，列出并讨论了两个样本中损伤留下的已知印记。总而言之，妊娠晚期人类胎儿肾脏中肾单位形成的数据相对缺乏，这要求从深入研究开始，以便可以设计出治疗性延长肾形成的概念。列出并讨论了两个样本中损伤留下的已知印记。总而言之，妊娠晚期人类胎儿肾脏中肾单位形成的数据相对缺乏，这要求从深入研究开始，以便可以设计出治疗性延长肾形成的概念。列出并讨论了两个样本中损伤留下的已知印记。总而言之，妊娠晚期人类胎儿肾脏中肾单位形成的数据相对缺乏，这要求从深入研究开始，以便可以设计出治疗性延长肾形成的概念。