In the 1980', vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) was identified and shown to be a key regulator of endothelial cell proliferation and migration, and vascular permeability. The essential role of VEGF and of VEGF receptors (VEGFRs) for the development of the embryonic vascular system has been established via gene disruption studies. This article summarizes the fundamental contributions that have been made in the early days of angiogenesis research to define the involvement of VEGF/VEGFRs in the developing vasculature.

中文翻译：

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发现VEGF在血管系统发育中的基本作用

在 1980 年，血管内皮生长因子 (VEGF)，也称为血管通透性因子 (VPF) 被鉴定并证明是内皮细胞增殖和迁移以及血管通透性的关键调节剂。已经通过基因破坏研究确定了 VEGF 和 VEGF 受体 (VEGFR) 在胚胎血管系统发育中的重要作用。本文总结了在血管生成研究的早期做出的基本贡献，以定义 VEGF/VEGFRs 在发展中的脉管系统中的参与。