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Breast density measured volumetrically in a clinical environment: cross-sectional study with photon counting technology.
Breast Cancer Research and Treatment ( IF 3.0 ) Pub Date : 2019-11-27 , DOI: 10.1007/s10549-019-05502-7
Jean L Browne 1 , Lilian Casas 1 , Guillermo Santandreu 1 , Ignacio Rodriguez 1 , Beatriz Navarro 1 , Francesc Tresserra 2 , M Angela Pascual 1
Affiliation  

OBJECTIVE Mammographic breast density (BDen), the ratio of glandular volume (GVol) to breast volume (BVol), is the second most prevalent risk factor for breast cancer (BC). Newly developed photon counting technology allows precise and systematic measurements in clinical practice. Our objective is to see how these parameters change with age in women with and without cancer. MATERIALS AND METHODS This retrospective study analyzed results of BDen, GVol, and BVol in 64,182 mammograms performed with photon counting technology on 32,448 consecutive women from April 2014 to December 2015. Only their first study was included. We excluded women with incomplete data or with breast implants. RESULTS Mean age of women without BC diagnosed during the study period was 52.1 ± 9.9. BC and was found in 263 women (0.81%). Mean age was 53.0 ± 10.4. BDen, GVol, and BVol were 14%, 24%, and 2% greater in women with BC (P < 0.001 for BDen and GVol and P = 0.02 for BVol). BDen and GVol diminished following similar patterns across age in both groups, with soft slopes before and after a steep drop from 50 to 60, probably due to menopause. CONCLUSION BDen diminishes with age in women with or without BC, but it is generally higher in women with BC. GVol could be a more robust indicator associated with BC risk than BDen. This technology can ease the way to studies of interventions to diminish BDen (or GVol) in the hope of diminishing BC incidence or predict if longitudinal changes are indicative of impending cancer.

中文翻译:

在临床环境中按体积测量的乳房密度:采用光子计数技术的横断面研究。

目的乳房X线照相术的乳腺密度(BDen),即腺体体积(GVol)与乳腺体积(BVol)之比,是乳腺癌(BC)的第二大流行风险因素。最新开发的光子计数技术可在临床实践中进行精确而系统的测量。我们的目标是观察这些参数在患有和不患有癌症的女性中如何随年龄变化。材料与方法这项回顾性研究分析了2014年4月至2015年12月使用光子计数技术对32,448名连续女性进行的64,182例乳房X光检查中BDen,GVol和BVol的结果。仅纳入了他们的第一项研究。我们排除了数据不完整或有乳房植入物的女性。结果在研究期间,未诊断为BC的女性平均年龄为52.1±9.9。不列颠哥伦比亚省,被发现于263名女性中(0.81%)。平均年龄为53.0±10.4。BDen,GVol,和BC分别比BC女性高14%,24%和2%(BDen和GVol的P <0.001,BVol的P = 0.02)。两组中的BDen和GVol随年龄的增长遵循相似的模式,在从50急剧下降至60之前和之后的软坡度可能是由于更年期造成的。结论BDen在有或没有BC的女性中随着年龄的增长而降低,但通常在具有BC的女性中更高。与BDen相比,GVol可能是与BC风险相关的更可靠的指标。这项技术可以简化旨在减少BDen(或GVol)的干预研究的方法,以期减少BC发病率或预测纵向变化是否预示着即将发生的癌症。在从50急剧下降到60之前和之后的软坡度,可能是由于更年期造成的。结论BDen在有或没有BC的女性中随着年龄的增长而降低,但通常在具有BC的女性中更高。与BDen相比,GVol可能是与BC风险相关的更可靠的指标。这项技术可以简化旨在减少BDen(或GVol)的干预研究的方法,以期减少BC发病率或预测纵向变化是否预示着即将发生的癌症。在从50急剧下降到60之前和之后的软坡度,可能是由于更年期造成的。结论BDen在有或没有BC的女性中随年龄的增长而降低,但通常在具有BC的女性中更高。与BDen相比,GVol可能是与BC风险相关的更可靠的指标。这项技术可以简化旨在减少BDen(或GVol)的干预研究的方法,以期减少BC发病率或预测纵向变化是否预示着即将发生的癌症。
更新日期:2019-11-01
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