Bovine leukemia virus (BLV) infects cattle worldwide and causes B-cell lymphoma in cattle. BLV has been identified in human breast and lung cancer and in blood, but the association of BLV and human cancer is controversial. In this study, we investigated the existence of BLV in 145 Japanese human blood cell lines and 54 human cancer cell lines, using a new highly sensitive PCR assay that can amplify even one copy of BLV using LTR primers different from those in previous studies on BLV provirus in breast cancer. All samples were found negative for BLV provirus, suggesting that BLV is unlikely to infect humans.

中文翻译：

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日本人血细胞系和人癌细胞系中不存在牛白血病病毒原病毒DNA。

牛白血病病毒（BLV）感染全世界的牛，并引起牛的B细胞淋巴瘤。已在人乳腺癌和肺癌以及血液中发现了BLV，但BLV与人癌症的关联尚存争议。在这项研究中，我们调查了145种日本人血细胞系和54种人类癌细胞系中BLV的存在，采用了一种新的高度敏感的PCR检测方法，该方法可以使用与以前的BLV研究不同的LTR引物扩增甚至一个拷贝的BLV。乳腺癌中的前病毒。所有样本均被发现对BLV原病毒呈阴性，这表明BLV不太可能感染人类。