During herpes simplex virus (HSV) latency, the viral genome is harbored in peripheral neurons in the absence of infectious virus but with the potential to restart infection. Advances in epigenetics have helped explain how viral gene expression is largely inhibited during latency. Paradoxically, at the same time, the view that latency is entirely silent has been eroding. This low-level noise has implications for our understanding of HSV latency and should not be ignored.

中文翻译：

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越接近我们，单纯疱疹病毒的等待时间就越吵。

在单纯疱疹病毒（HSV）潜伏期中，在没有感染性病毒的情况下，病毒基因组存在于周围神经元中，但有可能重新开始感染。表观遗传学的进展有助于解释在潜伏期病毒基因的表达如何被大大抑制。矛盾的是，与此同时，关于等待时间完全沉默的观点正在逐渐消失。这种低水平的噪声影响了我们对HSV延迟的理解，因此不应忽略。