Wound healing is a complex process and some agents have been reported to accelerate it. The aim of this study was to evaluate the healing effect of Eucerin-based ointments of lemon, sesame and olive oils on infected full-thickness wounds in rats. Wounds were created on the dorsal surface of Male Albino Wistar rats (n = 12). Wounds were treated with an Eucerin-based ointment containing either of lemon, sesame or olive oils (33% w/w) twice a day for 14 days. Histopathology results showed that contraction of wounds treated with lemon and sesame oils was higher than in the olive oil and control groups on days 10 and 14. In the lemon- and sesame-oil treated groups, on day 14, 50% of rat lesions were completely healed. Total number of inflammatory cells in lemon oil treatment group was significantly smaller than that of others on day 14 (p < 0.001). Also, thickness of the epidermal layer and rejuvenation of the hair follicles and other skin appendages was normal in lemon and sesame oil treated groups. The lemon and sesame oil ointments accelerated the healing process of wounds in macroscopic, morphological and morphmetrical analyses. Therefore, lemon and sesame oil ointments could be considered as alternative dressings for infected full-thickness wounds because of improved wound healing characteristics.

中文翻译：

---

不同草药油膏作为伤口愈合剂的制备及效果比较

伤口愈合是一个复杂的过程，据报道有些药物可以加速它。本研究的目的是评估基于优色林的柠檬、芝麻和橄榄油软膏对大鼠感染全层伤口的愈合效果。在雄性白化 ​​Wistar 大鼠 (n = 12) 的背表面上产生伤口。伤口用含有柠檬、芝麻或橄榄油（33% w/w）的优色林软膏治疗，每天两次，持续 14 天。组织病理学结果显示，在第 10 天和第 14 天，用柠檬油和芝麻油治疗的伤口收缩率高于橄榄油组和对照组。在柠檬和芝麻油治疗组中，第 14 天，50% 的大鼠病变是完全痊愈了。第14天柠檬油治疗组炎症细胞总数显着小于其他组（p < 0.001）。此外，柠檬油和芝麻油处理组的表皮层厚度和毛囊和其他皮肤附件的恢复正常。在宏观、形态学和形态测量分析中，柠檬和芝麻油软膏加速了伤口的愈合过程。因此，柠檬和芝麻油软膏可被视为感染全层伤口的替代敷料，因为它改善了伤口愈合特性。