Aims: To describe the epidemiology of peanut allergy (PA) in the UK over the last three decades.

Methods: PA patients were identified from the Clinical Practice Research Datalink between 1987 and 2015. Incidence and prevalence of PA were compared between 2000 and 2015. Prevalence and relative risk (RR) of atopic comorbidities, anaphylaxis, adrenaline prescriptions versus matched controls were calculated.

Results: Point prevalence of PA in the entire population and those <18 years increased from 31 to 202 and 116 to 635 per 100,000, respectively, between 2000 and 2015. Incidence increased from 8.6 to 18.2 per 100,000. Incidence in 2015 was 105 cases per 100,000 aged 0–4 years versus 13.4 per 100,000 aged 5+ years. Anaphylactic events affected 1.2% of the cases and 0.007% of the controls. The rate of adrenaline prescriptions was 5,910 per 100,000 person-years for PA patients. RRs for asthma, eczema and allergic rhinitis in PA patients versus controls were 4.5 (95% CI 4.2–4.8), 3.2 (3.1–3.4) and 2.6 (2.4–3.0), respectively.

Conclusions: The prevalence and incidence of PA increased markedly over the study period. PA was associated with atopic conditions and anaphylaxis. PA patients had increased adrenaline prescriptions.

目的：描述过去三十年来英国花生过敏（PA）的流行病学。

方法：从1987年至2015年间通过临床实践研究数据链鉴定出PA患者。比较了2000年至2015年间PA的发病率和患病率。计算了特应性合并症，过敏反应，肾上腺素处方药与相匹配的对照组的患病率和相对风险（RR）。

结果：在2000年至2015年之间，整个人口及<18岁人群的PA患病率分别从31增至202 / 100,000和116/635至100,000。发病率从8.6增至18.2 100,000。2015年的发病率是每10万名0-4岁的人有105例，而每10万5岁以上的人有13.4例。过敏反应影响了1.2％的病例和0.007％的对照。PA患者的肾上腺素处方率是每100,000人年5,910次。与对照组相比，PA患者的哮喘，湿疹和变应性鼻炎的RR分别为4.5（95％CI 4.2-4.8），3.2（3.1-3.4）和2.6（2.4-3.0）。

结论：在研究期间，PA的患病率和发病率显着增加。PA与特应性疾病和过敏反应有关。PA患者增加了肾上腺素处方。