BACKGROUND The prognosis for patients with colorectal cancer shows variation. The characteristics of colorectal cancer patients with signet-ring cell carcinoma (SRCC) are still not clear. MATERIALS AND METHODS A retrospective comparison was made of the data of signet-ring cell colorectal carcinoma patients operated on between 2009 and 2018 in respect of clinicopathological and operative results, morbidity, mortality, and long-term survival. RESULTS The study included a total of 34 patients comprising 26 (76%) males and 8 (24%) females with a mean age of 58 ± 11.7 years. Incidence of SRCC was determined as 1.8%. Lymphovascular invasion was determined in 22 (64%) patients. Tumors were determined as stage T2 in 8 (32%) patients, stage T3 in 9 (36%), and stage T4 in 8 (32%). According to the TNM classification, 5 (14.7%) patients were diagnosed with stage 1, 7 (20.6%) with stage 2, 15 (44.1%) with stage 3, and 7 (20.6%) with stage 4. The mean follow-up period was 40.6 ± 30.4 months, and mean disease-free follow-up was determined as 33.1 ± 36.1 months. Fifteen (44.1%) patients died because of the disease. CONCLUSION Although SRCC is a poor prognostic factor, it should be kept in mind when determining adjuvant therapies and prognosis of patients determined with advanced-stage SRCC.

中文翻译：

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结直肠癌预后：印戒细胞的影响。

背景技术 结直肠癌患者的预后存在差异。结直肠癌合并印戒细胞癌（SRCC）的特征尚不明确。材料与方法 回顾性比较2009-2018年印戒细胞结直肠癌患者的临床病理和手术结果、发病率、病死率和远期生存情况。结果 本研究共纳入 34 名患者，其中男性 26 名（76%），女性 8 名（24%），平均年龄 58 ± 11.7 岁。SRCC 的发生率为 1.8%。在 22 名 (64%) 患者中确定了淋巴血管侵犯。8 例 (32%) 患者的肿瘤被确定为 T2 期，9 例 (36%) 为 T3 期，8 例 (32%) 为 T4 期。根据 TNM 分类，5 (14. 7%) 患者被诊断为第 1 期，第 2 期为 7 (20.6%)，第 3 期为 15 (44.1%)，第 4 期为 7 (20.6%)。平均随访时间为 40.6 ± 30.4 个月，平均无病随访时间确定为 33.1 ± 36.1 个月。15 名（44.1%）患者死于该病。结论 尽管 SRCC 是预后不良的因素，但在确定晚期 SRCC 患者的辅助治疗和预后时应牢记这一点。