Background Cutaneous and renal glomerular vasculopathy (CRGV) is a condition of unknown aetiology involving microvascular thrombosis. It has recently been described in over 160 dogs in the United Kingdom and usually has a grave prognosis. To date, this condition has not been described in dogs residing in the Republic of Ireland. Case presentation Three dogs presented to University College Dublin Veterinary Hospital (UCDVH) for investigation of rapidly progressive skin lesions. All dogs were diagnosed with CRGV on post-mortem examination. All three dogs had azotaemia on presentation or rapidly developed azotaemia, and all were euthanased because of progression of clinical signs and likelihood of CRGV. One dog was affected by seizure-like episodes and had thrombotic microangiopathy evident within the cerebrum. Conclusions CRGV occurs in dogs residing in the Republic of Ireland and is a differential for cases presenting with skin lesions and azotaemia. The histopathological lesions of CRGV can also affect the brain leading to neurological signs such as seizures. Owners and veterinarians should be aware that this condition can occur in dogs in Ireland.

中文翻译：

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爱尔兰共和国的犬皮肤和肾小球血管病：三例病例的描述。

背景皮肤和肾小球血管病（CRGV）是一种病因不明的疾病，涉及微血管血栓形成。它最近在英国的 160 多只狗中被描述，并且通常预后很差。迄今为止，尚未在居住在爱尔兰共和国的狗中描述过这种情况。病例介绍 三只狗被送到都柏林大学兽医医院 (UCDVH) 以调查快速进展的皮肤病变。所有的狗在尸检时都被诊断出患有 CRGV。所有三只狗都出现氮质血症或迅速发展为氮质血症，并且由于临床症状的进展和 CRGV 的可能性而全部被安乐死。一只狗受到癫痫样发作的影响，并且大脑内有明显的血栓性微血管病。结论 CRGV 发生在居住在爱尔兰共和国的狗身上，并且是皮肤损伤和氮质血症病例的差异。CRGV 的组织病理学病变也会影响大脑，导致癫痫发作等神经系统症状。业主和兽医应该意识到这种情况可能发生在爱尔兰的狗身上。