Tinea pedis has been associated with Trichophyton rubrum infection. However, it’s not clear whether other microbes were implicated in disease pathogenesis. The composition of microbial communities of patients with tinea pedis and healthy controls were analyzed to identify the characteristics of tinea pedis and differences associated with clinical patterns. We found that microbial community structures were different in patients with tinea pedis compared with healthy controls. Moreover, skin microbiome varied in different forms of tinea pedis. Healthy controls exhibited greater fungal diversity than patients with tinea pedis. In patients with tinea pedis, the dominant bacterial and fungal genera were Staphylococcus and Trichophyton. Compared with healthy controls, Corynebacterium tuberculostearicum was decreased and T. rubrum was increased. C. tuberculostearicum was more abundant in vesicular tinea pedis than in hyperkeratotic and interdigital tinea pedis. Interdigital tinea pedis had a higher detection rate of Corynebacterium minutissimum and T. rubrum than the other forms. These results indicated that bacterial microbes may take part in the development of tinea pedis.

中文翻译：

---

Tinea Pedis中皮肤微生物组的表征。

足癣与红癣毛癣菌感染有关。但是，尚不清楚其他微生物是否与疾病的发病机制有关。分析了足癣患者和健康对照组的微生物群落组成，以鉴定足癣的特征和与临床模式相关的差异。我们发现，与健康对照组相比，足癣患者的微生物群落结构不同。此外，皮肤微生物组在足癣的不同形式中也不同。健康对照显示的真菌多样性高于足癣患者。足癣患者的主要细菌和真菌属是葡萄球菌和毛癣菌。与正常对照组相比，棒状杆菌tuberculostearicum下降和红色毛癣菌增加。囊性足癣中的结核分枝杆菌比角化过度和趾间癣更丰富。叉指足癣具有检出率较高棒状杆菌minutissimum和红色毛癣菌比其它形式。这些结果表明细菌微生物可能参与足癣的发展。