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Synthetic Biology Perspectives of Microbial Enzymes and Their Innovative Applications.
Indian Journal of Microbiology ( IF 2.1 ) Pub Date : 2019-08-23 , DOI: 10.1007/s12088-019-00819-9
Pratyoosh Shukla 1
Affiliation  

Microbial enzymes are high in demand and there is focus on their efficient, cost effective and eco-friendly production. The relevant microbial enzymes for respective industries needs to be identified but the conventional technologies don’t have much edge over it. So, there is more attention towards high throughput methods for production of efficient enzymes. The enzymes produced by microbes need to be modified to bear the extreme conditions of the industries in order to get prolific outcomes and here the synthetic biology tools may be augmented to modify such microbes and enzymes. These tools are applied to synthesize novel and efficient enzymes. Use of computational tools for enzyme modification has provided new avenues for faster and specific modification of enzymes in a shorter time period. This review focuses on few important enzymes and their modification through synthetic biology tools including genetic modification, nanotechnology, post translational modification.

中文翻译:

微生物酶的合成生物学观点及其创新应用。

微生物酶的需求量很大,并且关注其高效,成本有效和生态友好的生产。需要确定与各个行业相关的微生物酶,但是传统技术没有太多优势。因此,对于生产有效酶的高通量方法有更多的关注。为了获得多产的结果,需要对微生物产生的酶进行修饰以适应工业的极端条件,在这里可以增加合成生物学工具来修饰此类微生物和酶。这些工具可用于合成新型高效酶。使用用于酶修饰的计算工具已经提供了新的途径,可以在较短的时间内更快地进行特定的酶修饰。
更新日期:2019-08-23
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